Laboratory Testing in Thyroid Conditions - Pitfalls and Clinical Utility.
Calcitonin
Free thyroxine
Free triiodothyronine
Thyroglobulin
Thyroglobulin antibodies
Thyroid function test
Thyroid peroxidase antibodies
Thyroid-stimulating hormone
Thyroid-stimulating hormone receptor antibodies
Journal
Annals of laboratory medicine
ISSN: 2234-3814
Titre abrégé: Ann Lab Med
Pays: Korea (South)
ID NLM: 101571172
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
21
04
2018
revised:
29
05
2018
accepted:
02
09
2018
entrez:
15
9
2018
pubmed:
15
9
2018
medline:
24
11
2018
Statut:
ppublish
Résumé
Thyroid disorders are common, affecting more than 10% of people in the US, and laboratory tests are integral in the management of these conditions. The repertoire of thyroid tests includes blood tests for thyroid-stimulating hormone (TSH), free thyroxine, free triiodothyronine, thyroglobulin (Tg), thyroglobulin antibodies (Tg-Ab), thyroid peroxidase antibodies (TPO-Ab), TSH receptor antibodies (TRAb), and calcitonin. TSH and free thyroid hormone tests are frequently used to assess the functional status of the thyroid. TPO-Ab and TRAb tests are used to diagnose Hashimoto's thyroiditis and Graves' disease, respectively. Tg and calcitonin are important tumor markers used in the management of differentiated thyroid carcinoma and medullary thyroid carcinoma (MTC), respectively. Procalcitonin may replace calcitonin as a biomarker for MTC. Apart from understanding normal thyroid physiology, it is important to be familiar with the possible pitfalls and caveats in the use of these tests so that they can be interpreted properly and accurately. When results are discordant, clinicians and laboratorians should be mindful of possible assay interferences and/or the effects of concurrent medications. In addition, thyroid function may appear abnormal in the absence of actual thyroid dysfunction during pregnancy and in critical illness. Hence, it is important to consider the clinical context when interpreting results. This review aims to describe the above-mentioned blood tests used in the diagnosis and management of thyroid disorders, as well as the pitfalls in their interpretation. With due knowledge and care, clinicians and laboratorians will be able to fully appreciate the clinical utility of these important laboratory tests.
Identifiants
pubmed: 30215224
pii: 39.3
doi: 10.3343/alm.2019.39.1.3
pmc: PMC6143469
doi:
Substances chimiques
Autoantibodies
0
Immunoglobulins, Thyroid-Stimulating
0
anti-thyroglobulin
0
thyrotropin-binding inhibitory immunoglobulin
0
Triiodothyronine
06LU7C9H1V
Thyrotropin
9002-71-5
Calcitonin
9007-12-9
Thyroglobulin
9010-34-8
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-14Informations de copyright
© The Korean Society for Laboratory Medicine.
Déclaration de conflit d'intérêts
No potential conflicts of interest relevant to this article were reported.
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