Striatal presynaptic dopaminergic dysfunction in gambling disorder: A
Adolescent
Adult
Aged
Anhedonia
/ physiology
Corpus Striatum
/ chemistry
Decision Making
/ physiology
Dopamine
/ metabolism
Dopamine Plasma Membrane Transport Proteins
/ metabolism
Female
Gambling
/ physiopathology
Humans
Impulsive Behavior
/ physiology
Male
Middle Aged
Psychometrics
Radiopharmaceuticals
Reward
Signal Transduction
/ physiology
Synapses
/ metabolism
Tomography, Emission-Computed, Single-Photon
Tropanes
Young Adult
Iowa gambling task (IGT)
basal ganglia (putamen, caudate)
behavioral addiction
dopamine transporter (DAT)
neuroimaging
reward-based decision making
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
05
12
2017
revised:
11
05
2018
accepted:
01
08
2018
pubmed:
19
9
2018
medline:
4
8
2020
entrez:
19
9
2018
Statut:
ppublish
Résumé
Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 healthy controls in terms of striatal DAT availability, and we explore its association with reward-based decision making. We performed
Substances chimiques
Dopamine Plasma Membrane Transport Proteins
0
Radiopharmaceuticals
0
Tropanes
0
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
155797-99-2
Dopamine
VTD58H1Z2X
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1077-1086Informations de copyright
© 2018 Society for the Study of Addiction.