β-Adrenergic signaling blocks murine CD8
Adrenergic beta-Agonists
/ pharmacology
Adrenergic beta-Antagonists
/ pharmacology
Animals
CD8-Positive T-Lymphocytes
/ cytology
Cells, Cultured
Female
Glucose
/ immunology
Immune Tolerance
/ drug effects
Isoproterenol
/ pharmacology
Lymphocyte Activation
/ drug effects
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Propranolol
/ pharmacology
Receptors, Adrenergic, beta-2
/ genetics
Signal Transduction
/ drug effects
Adrenergic signaling
CD8+ T-cell suppression
Glycolysis
Metabolic reprogramming
T-cell activation
Tumor immunology
Journal
Cancer immunology, immunotherapy : CII
ISSN: 1432-0851
Titre abrégé: Cancer Immunol Immunother
Pays: Germany
ID NLM: 8605732
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
06
03
2018
accepted:
07
09
2018
pubmed:
20
9
2018
medline:
29
1
2019
entrez:
20
9
2018
Statut:
ppublish
Résumé
Primary and secondary lymphoid organs are heavily innervated by the autonomic nervous system. Norepinephrine, the primary neurotransmitter secreted by post-ganglionic sympathetic neurons, binds to and activates β-adrenergic receptors expressed on the surface of immune cells and regulates the functions of these cells. While it is known that both activated and memory CD8
Identifiants
pubmed: 30229289
doi: 10.1007/s00262-018-2243-8
pii: 10.1007/s00262-018-2243-8
pmc: PMC6326964
mid: NIHMS1002277
doi:
Substances chimiques
Adrenergic beta-Agonists
0
Adrenergic beta-Antagonists
0
Receptors, Adrenergic, beta-2
0
Propranolol
9Y8NXQ24VQ
Glucose
IY9XDZ35W2
Isoproterenol
L628TT009W
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11-22Subventions
Organisme : NCI NIH HHS
ID : P50 CA159981
Pays : United States
Organisme : The Peter T. Rowley Breast Cancer Research Grant
ID : C028252
Organisme : NCI NIH HHS
ID : R01 CA205246
Pays : United States
Organisme : NIH HHS
ID : 1R50CA211108
Pays : United States
Organisme : NCI NIH HHS
ID : R01CA205246
Pays : United States
Organisme : NCI NIH HHS
ID : P30CA016056
Pays : United States
Organisme : NIH HHS
ID : S10OD0189693
Pays : United States
Organisme : NIAID NIH HHS
ID : T35 AI089693
Pays : United States
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