Biotechnological Advances in Bacterial Microcompartment Technology.
bacterial microcompartments
metabolic engineering
metabolism
protein engineering
shell
synthetic biology
Journal
Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
22
06
2018
revised:
22
08
2018
accepted:
23
08
2018
pubmed:
22
9
2018
medline:
18
12
2019
entrez:
22
9
2018
Statut:
ppublish
Résumé
Bacterial microcompartments (BMCs) represent proteinaceous macromolecular nanobioreactors that are found in a broad range of bacteria, and which are associated with either anabolic or catabolic processes. They consist of a semipermeable outer shell that packages a central metabolic enzyme or pathway, providing both enhanced flux and protection against toxic intermediates. Recombinant production of BMCs has led to their repurposing with the incorporation of altogether new pathways. Deconstructing BMCs into their component parts has shown that some individual shell proteins self-associate into filaments that can be further modified into a cytoplasmic scaffold, or cytoscaffold, to which enzymes/proteins can be targeted. BMCs therefore represent a modular system that is highly suited for engineering biological systems for useful purposes.
Identifiants
pubmed: 30236905
pii: S0167-7799(18)30246-4
doi: 10.1016/j.tibtech.2018.08.006
pii:
doi:
Substances chimiques
Macromolecular Substances
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
325-336Subventions
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.