Host


Journal

Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500

Informations de publication

Date de publication:
15 01 2019
Historique:
received: 21 03 2018
revised: 16 07 2018
accepted: 25 09 2018
pubmed: 30 9 2018
medline: 28 2 2020
entrez: 30 9 2018
Statut: ppublish

Résumé

Heritable genetic variations can affect the inflammatory tumor microenvironment, which can ultimately affect cancer susceptibility and clinical outcomes. Recent evidence indicates that IDO2, a positive modifier in inflammatory disease models, is frequently upregulated in pancreatic ductal adenocarcinoma (PDAC). A unique feature of PDAC development was notably decreased in the The results of this study provide genetic support for IDO2 as a contributing factor in PDAC development and argue that

Identifiants

pubmed: 30266763
pii: 1078-0432.CCR-18-0814
doi: 10.1158/1078-0432.CCR-18-0814
pmc: PMC6335160
mid: NIHMS1508664
doi:

Substances chimiques

Biomarkers, Tumor 0
IDO2 protein, human 0
Indoleamine-Pyrrole 2,3,-Dioxygenase 0
KRAS protein, human 0
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

724-734

Subventions

Organisme : NCI NIH HHS
ID : P30 CA056036
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA191191
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA212600
Pays : United States

Informations de copyright

©2018 American Association for Cancer Research.

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Auteurs

Avinoam Nevler (A)

Departments of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Sidney Kimmel Medical College and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
The Dr. P. Borenstein Talpiot Medical Leadership Program (2012), ChaimSheba Medical Center, Israel.

Alexander J Muller (AJ)

Sidney Kimmel Medical College and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.

Erika Sutanto-Ward (E)

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.

James B DuHadaway (JB)

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.

Kei Nagatomo (K)

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.

Eric Londin (E)

Departments of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Kevin O'Hayer (K)

Departments of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

Joseph A Cozzitorto (JA)

Departments of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

Harish Lavu (H)

Departments of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Sidney Kimmel Medical College and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

Theresa P Yeo (TP)

Departments of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Sidney Kimmel Medical College and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

Mark Curtis (M)

Departments of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Tatiana Villatoro (T)

Departments of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Benjamin E Leiby (BE)

Sidney Kimmel Medical College and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Division of Biostatistics, Thomas Jefferson University, Philadelphia, Pennsylvania.

Laura Mandik-Nayak (L)

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.

Jordan M Winter (JM)

Departments of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Sidney Kimmel Medical College and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

Charles J Yeo (CJ)

Departments of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Sidney Kimmel Medical College and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

George C Prendergast (GC)

Sidney Kimmel Medical College and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania. prendergast@limr.org.
Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.
Departments of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Jonathan R Brody (JR)

Departments of Surgery and the Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
Sidney Kimmel Medical College and Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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