Snakegourd root/Astragalus polysaccharide hydrogel preparation and application in 3D printing.
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
03
02
2018
revised:
19
08
2018
accepted:
01
10
2018
pubmed:
10
10
2018
medline:
23
1
2019
entrez:
10
10
2018
Statut:
ppublish
Résumé
Hydrogels have good water retention, biocompatibility and biodegradability, so they are well used in the medical industry. Here, we have active polysaccharide exacted from Chinese traditional medicine and carboxymethyl chitosan cross-linked to form hydrogel and characterized them by Scanning electron microscopy, FTIR analysis, swelling, degradation, release and cytotoxicity tests. We printed the composite hydrogel into patches with three different shapes by Hot-Melt extruded 3D printer and studied the effects of different shapes on the release of drug. The results show, under acidic or alkaline conditions, the BSA cumulative release rate of the three hydrogel patches with different shape range from 49% to 89%. Therefore, there is a significant difference in the release between circular, cube and rectangular shape. Through the study, we found that the hydrogels we prepared have excellent potential for future applications in drug delivery system.
Identifiants
pubmed: 30300696
pii: S0141-8130(18)30579-8
doi: 10.1016/j.ijbiomac.2018.10.008
pii:
doi:
Substances chimiques
Drug Carriers
0
Hydrogels
0
Polysaccharides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
309-316Informations de copyright
Copyright © 2018. Published by Elsevier B.V.