Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation.
CASIN
Cdc42
T cells
Th2 differentiation
animal models
asthma
Journal
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
ISSN: 1365-2222
Titre abrégé: Clin Exp Allergy
Pays: England
ID NLM: 8906443
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
28
02
2018
revised:
26
06
2018
accepted:
25
07
2018
pubmed:
12
10
2018
medline:
25
9
2020
entrez:
12
10
2018
Statut:
ppublish
Résumé
Asthma is an allergic airway inflammation-driven disease that affects more than 300 million people world-wide. Targeted therapies for asthma are largely lacking. Although asthma symptoms can be prevented from worsening, asthma development cannot be prevented. Cdc42 GTPase has been shown to regulate actin cytoskeleton, cell proliferation and survival. To investigate the role and targeting of Cdc42 in Th2 cell differentiation and Th2-mediated allergic airway inflammation. Post-thymic Cdc42-deficient mice were generated by crossing Cdc42 Post-thymic deletion of Cdc42 led to reduced peripheral CD8 Cdc42 is required for Th2 cell differentiation and allergic airway inflammation, and rational targeting Cdc42 may serve as a preventive but not therapeutic approach for asthma control.
Sections du résumé
BACKGROUND
Asthma is an allergic airway inflammation-driven disease that affects more than 300 million people world-wide. Targeted therapies for asthma are largely lacking. Although asthma symptoms can be prevented from worsening, asthma development cannot be prevented. Cdc42 GTPase has been shown to regulate actin cytoskeleton, cell proliferation and survival.
OBJECTIVES
To investigate the role and targeting of Cdc42 in Th2 cell differentiation and Th2-mediated allergic airway inflammation.
METHODS
Post-thymic Cdc42-deficient mice were generated by crossing Cdc42
RESULTS
Post-thymic deletion of Cdc42 led to reduced peripheral CD8
CONCLUSION AND CLINICAL RELEVANCE
Cdc42 is required for Th2 cell differentiation and allergic airway inflammation, and rational targeting Cdc42 may serve as a preventive but not therapeutic approach for asthma control.
Identifiants
pubmed: 30307073
doi: 10.1111/cea.13293
pmc: PMC6310654
mid: NIHMS992446
doi:
Substances chimiques
Cdc42 protein, mouse
0
cdc42 GTP-Binding Protein
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
92-107Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM108661
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA198358
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL141499
Pays : United States
Informations de copyright
© 2018 John Wiley & Sons Ltd.
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