ACE2 and ACE in acute and chronic rejection after human heart transplantation.
Acute Disease
Adult
Angiotensin-Converting Enzyme 2
Biomarkers
/ metabolism
Biopsy
Chronic Disease
Coronary Angiography
Female
Follow-Up Studies
Graft Rejection
/ diagnosis
Heart Failure
/ surgery
Heart Transplantation
/ adverse effects
Humans
Male
Middle Aged
Myocardium
/ enzymology
Peptidyl-Dipeptidase A
/ metabolism
Pilot Projects
Prognosis
Retrospective Studies
Severity of Illness Index
Time Factors
Transplantation, Homologous
Acute rejection
Angiotensin-converting enzyme
Angiotensin-converting enzyme 2
Chronic allograft vasculopathy
Heart transplantation
Journal
International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291
Informations de publication
Date de publication:
15 Jan 2019
15 Jan 2019
Historique:
received:
02
03
2018
revised:
07
09
2018
accepted:
01
10
2018
pubmed:
14
10
2018
medline:
20
7
2019
entrez:
14
10
2018
Statut:
ppublish
Résumé
The authors sought to evaluate cardiac activity of angiotensin-converting enzyme (ACE) and ACE2 after heart transplantation (HT) and its relation with acute rejection (AR) and chronic allograft vasculopathy (CAV). The renin-angiotensin system is altered in heart failure and HT. However, ACE and ACE2 activities in post-HT acute and chronic rejection have not been previously studied. HT patients (n = 45) were included when appropriate serial endomyocardial biopsies (EMB) and coronary angiography were available for analysis. In 21 patients, three post-HT time points were selected for CAV study in EMB tissue: basal (0-3 wks), second (2-3 months) and third (4-5 months). At 10 years post-HT, CAV was evaluated by coronary angiography (CA) and patients were grouped by degree of CAV: 0-1, non-CAV (n = 15) and 2-3, CAV (n = 6). For the AR study, 28 HT patients with evidence of one EMB rejection at grade 3 and two EMB grade 1A and/or 1B rejections were selected. Post-HT, ACE2 activity was increased in the CAV group, compared to non-CAV. Patients with AR showed increased ACE, but not ACE2, activity. Our results suggest that early post-HT cardiac ACE2 activity may have an important role in CAV development. In contrast, ACE activity was increased in AR. The renin-angiotensin system seems to be altered after HT and strategies to balance the system may be useful.
Sections du résumé
OBJECTIVES
OBJECTIVE
The authors sought to evaluate cardiac activity of angiotensin-converting enzyme (ACE) and ACE2 after heart transplantation (HT) and its relation with acute rejection (AR) and chronic allograft vasculopathy (CAV).
BACKGROUND
BACKGROUND
The renin-angiotensin system is altered in heart failure and HT. However, ACE and ACE2 activities in post-HT acute and chronic rejection have not been previously studied.
METHODS
METHODS
HT patients (n = 45) were included when appropriate serial endomyocardial biopsies (EMB) and coronary angiography were available for analysis. In 21 patients, three post-HT time points were selected for CAV study in EMB tissue: basal (0-3 wks), second (2-3 months) and third (4-5 months). At 10 years post-HT, CAV was evaluated by coronary angiography (CA) and patients were grouped by degree of CAV: 0-1, non-CAV (n = 15) and 2-3, CAV (n = 6). For the AR study, 28 HT patients with evidence of one EMB rejection at grade 3 and two EMB grade 1A and/or 1B rejections were selected.
RESULTS
RESULTS
Post-HT, ACE2 activity was increased in the CAV group, compared to non-CAV. Patients with AR showed increased ACE, but not ACE2, activity.
CONCLUSIONS
CONCLUSIONS
Our results suggest that early post-HT cardiac ACE2 activity may have an important role in CAV development. In contrast, ACE activity was increased in AR. The renin-angiotensin system seems to be altered after HT and strategies to balance the system may be useful.
Identifiants
pubmed: 30314840
pii: S0167-5273(18)31428-1
doi: 10.1016/j.ijcard.2018.10.002
pii:
doi:
Substances chimiques
Biomarkers
0
Peptidyl-Dipeptidase A
EC 3.4.15.1
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-64Informations de copyright
Copyright © 2018. Published by Elsevier B.V.