The blocking of kappa-opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization.
amphetamine sensitization
dopamine
dorsolateral striatum
kappa-opioid receptor
no-net flux microdialysis
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
08
08
2018
revised:
25
09
2018
accepted:
05
10
2018
pubmed:
14
10
2018
medline:
28
10
2019
entrez:
14
10
2018
Statut:
ppublish
Résumé
Kappa-opioid receptors (KOR) control dopamine (DA) levels in the striatum and contribute significantly to the progression of drug addiction. Repeated exposure to psychostimulants has been associated with up-regulated KOR activity and increased DA levels in dorsal striatum. However, it has not been tested if both processes are linked. In this work, we studied if a mechanism mediated by KOR is contributing to the increase in DA levels in the dorsolateral striatum (DLS) after amphetamine (AMPH) sensitization. The AMPH sensitization was assessed after single or repeated once-a-day AMPH injections (1 mg/kg). Only repeated AMPH exposure produced a significant locomotor sensitization. No-net flux microdialysis was used to assess basal DA dialysate, DA extracellular concentration (C
Substances chimiques
Central Nervous System Stimulants
0
Receptors, Opioid, kappa
0
Amphetamine
CK833KGX7E
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
348-358Informations de copyright
© 2018 International Society for Neurochemistry.