Tunable drug release from nanofibers coated with blank cellulose acetate layers fabricated using tri-axial electrospinning.

Cellulose / analogs & derivatives Drug Carriers / chemistry Drug Liberation Gliadin / chemistry Ibuprofen / chemistry Nanofibers / chemistry Particle Size Triticum / chemistry
1,1,1,3,3,3-hexafluoro-2-propanol (PubChem CID:13529) Acetic acid (PubChem CID: 176) Acetone (PubChem CID: 180) Basic fuchsin (PubChem CID: 12447) Cellulose acetate (PubChem CID: 3084039) Cellulose acetate nanocoating Detachable tri-layer spinneret Gliadin (PubChem CID: 17787981) Ibuprofen (PubChem CID: 3672) Linear drug release Methylene blue (PubChem CID: 6099) Modified triaxial electrospinning Process–nanostructure–performance relationship Structural nanohybrids Trifluoroacetic acid (PubChem CID: 6422)

Journal

Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156

Informations de publication

Date de publication:
01 Jan 2019
Historique:
received: 24 08 2018
revised: 22 09 2018
accepted: 22 09 2018
entrez: 16 10 2018
pubmed: 16 10 2018
medline: 28 11 2018
Statut: ppublish

Résumé

In this study, novel core-shell nanostructures were fabricated through a modified triaxial electrospinning process. These comprised a drug-protein nanocomposite coated with a thin cellulose acetate (CA) shell. They were generated through the simultaneous treatment of an outer solvent, an unelectrospinnable middle fluid, and an electrospinnable core solution in triaxial electrospinning. SEM and TEM results revealed that the core-shell nanofibers had linear and cylindrical morphologies with a diameter from 0.66 to 0.87 μm, and distinct core-shell structures with a shell thickness from 1.8 to 11.6 nm. The presence of a CA coating eliminated the initial burst release of ibuprofen seen from a monolithic drug-protein composite, and allowed us to precisely manipulate the drug release (for a 90% percentage) over a time period from 23.5 to 43.9 h in a tunable manner. Mathematical relationships between the processing conditions, the nanostructures produced, and their functional performance were elucidated.

Identifiants

DOI: 10.1016/j.carbpol.2018.09.061 PMID: 30318208
pubmed: 30318208
pii: S0144-8617(18)31135-4
doi: 10.1016/j.carbpol.2018.09.061
pii:
doi:

Substances chimiques

Drug Carriers 0
acetylcellulose 3J2P07GVB6
Cellulose 9004-34-6
Gliadin 9007-90-3
Ibuprofen WK2XYI10QM

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

228-237

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Yaoyao Yang (Y)

School of Materials Science & Engineering, University of Shanghai for Science & Technology, Shanghai 200093, China.

Wenbing Li (W)

School of Chemistry & Chemical Engineering, Wuhan University of Science & Technology, Wuhan 430081, China.

Deng-Guang Yu (DG)

School of Materials Science & Engineering, University of Shanghai for Science & Technology, Shanghai 200093, China. Electronic address: ydg017@usst.edu.cn.

Guanhua Wang (G)

School of Chemistry & Chemical Engineering, Wuhan University of Science & Technology, Wuhan 430081, China.

Gareth R Williams (GR)

UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.

Zhu Zhang (Z)

Department of Internal Medicine, The Hospital of Wuhan University of Science & Technology, Wuhan 430081, China. Electronic address: zhangzhu75@wust.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Biopolymères › Cellulose › Tunable drug release from nanofibers coated...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Tunable drug release from nanofibers coated...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › Tunable drug release from nanofibers coated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Protéines de stockage des graines › Prolamines › Glutens › Gliadine › Tunable drug release from nanofibers coated...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Phénylpropionates › Ibuprofène › Tunable drug release from nanofibers coated...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanofibres › Tunable drug release from nanofibers coated...
questionsmedicales.fr › Phénomènes chimiques › Taille de particule › Tunable drug release from nanofibers coated...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Poaceae › Triticum › Tunable drug release from nanofibers coated...