Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled trial.
Mendelian randomisation
dietary intervention
green tea
lycopene
prostate cancer
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
21
03
2018
revised:
06
09
2018
accepted:
24
09
2018
pubmed:
17
10
2018
medline:
10
7
2019
entrez:
17
10
2018
Statut:
ppublish
Résumé
Lycopene and green tea consumption have been observationally associated with reduced prostate cancer risk, but the underlying mechanisms have not been fully elucidated. We investigated the effect of factorial randomisation to a 6-month lycopene and green tea dietary advice or supplementation intervention on 159 serum metabolite measures in 128 men with raised PSA levels (but prostate cancer-free), analysed by intention-to-treat. The causal effects of metabolites modified by the intervention on prostate cancer risk were then assessed by Mendelian randomisation, using summary statistics from 44,825 prostate cancer cases and 27,904 controls. The systemic effects of lycopene and green tea supplementation on serum metabolic profile were comparable to the effects of the respective dietary advice interventions (R
Identifiants
pubmed: 30325021
doi: 10.1002/ijc.31929
pmc: PMC6491994
doi:
Substances chimiques
Tea
0
Pyruvic Acid
8558G7RUTR
Prostate-Specific Antigen
EC 3.4.21.77
Lycopene
SB0N2N0WV6
Banques de données
ISRCTN
['ISRCTN20141297']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1918-1928Subventions
Organisme : Cancer Research UK (CRUK)
ID : C11046/A10052C18281/A19169
Pays : International
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/5
Pays : United Kingdom
Organisme : Cancer Research UK (CRUK)
ID : C11046/A10052
Pays : International
Organisme : Department of Health
ID : HTA 96/20/99
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/ 5MC_UU_12013/1
Pays : United Kingdom
Organisme : Cancer Research UK (CRUK)
ID : C18281/A19169
Pays : International
Organisme : Wellcome Trust
ID : WT099874MA
Pays : United Kingdom
Informations de copyright
© 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
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