Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects.
Adult
Alcoholism
/ diagnostic imaging
Amphetamine-Related Disorders
/ diagnostic imaging
Brain
/ diagnostic imaging
Cerebral Cortex
/ diagnostic imaging
Cocaine-Related Disorders
/ diagnostic imaging
Female
Gray Matter
/ diagnostic imaging
Humans
Male
Marijuana Abuse
/ diagnostic imaging
Methamphetamine
Middle Aged
Organ Size
Substance-Related Disorders
/ diagnostic imaging
Support Vector Machine
Tobacco Use Disorder
/ diagnostic imaging
Young Adult
Mega-Analysis
Structural MRI
Substance-Related Disorders
Journal
The American journal of psychiatry
ISSN: 1535-7228
Titre abrégé: Am J Psychiatry
Pays: United States
ID NLM: 0370512
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
pubmed:
20
10
2018
medline:
22
11
2019
entrez:
20
10
2018
Statut:
ppublish
Résumé
Although lower brain volume has been routinely observed in individuals with substance dependence compared with nondependent control subjects, the brain regions exhibiting lower volume have not been consistent across studies. In addition, it is not clear whether a common set of regions are involved in substance dependence regardless of the substance used or whether some brain volume effects are substance specific. Resolution of these issues may contribute to the identification of clinically relevant imaging biomarkers. Using pooled data from 14 countries, the authors sought to identify general and substance-specific associations between dependence and regional brain volumes. Brain structure was examined in a mega-analysis of previously published data pooled from 23 laboratories, including 3,240 individuals, 2,140 of whom had substance dependence on one of five substances: alcohol, nicotine, cocaine, methamphetamine, or cannabis. Subcortical volume and cortical thickness in regions defined by FreeSurfer were compared with nondependent control subjects when all sampled substance categories were combined, as well as separately, while controlling for age, sex, imaging site, and total intracranial volume. Because of extensive associations with alcohol dependence, a secondary contrast was also performed for dependence on all substances except alcohol. An optimized split-half strategy was used to assess the reliability of the findings. Lower volume or thickness was observed in many brain regions in individuals with substance dependence. The greatest effects were associated with alcohol use disorder. A set of affected regions related to dependence in general, regardless of the substance, included the insula and the medial orbitofrontal cortex. Furthermore, a support vector machine multivariate classification of regional brain volumes successfully classified individuals with substance dependence on alcohol or nicotine relative to nondependent control subjects. The results indicate that dependence on a range of different substances shares a common neural substrate and that differential patterns of regional volume could serve as useful biomarkers of dependence on alcohol and nicotine.
Identifiants
pubmed: 30336705
doi: 10.1176/appi.ajp.2018.17040415
pmc: PMC6427822
mid: NIHMS1002848
doi:
Substances chimiques
Methamphetamine
44RAL3456C
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-128Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA013892
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA014100
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024925
Pays : United States
Organisme : NIAAA NIH HHS
ID : K99 AA025401
Pays : United States
Organisme : NIDA NIH HHS
ID : PL1 DA024859
Pays : United States
Organisme : NIAAA NIH HHS
ID : R00 AA025401
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA038381
Pays : United States
Organisme : NIAAA NIH HHS
ID : F31 AA027169
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA041528
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA020726
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT010627
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA024635
Pays : United States
Organisme : NIDA NIH HHS
ID : K25 DA040032
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA021449
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117601
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA023248
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA047119
Pays : United States
Organisme : NIDA NIH HHS
ID : K02 DA026990
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA018307
Pays : United States
Commentaires et corrections
Type : ErratumIn
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