The association between AB blood group and neonatal disease.
ABO Blood-Group System
/ blood
Female
Genetic Predisposition to Disease
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal
Male
Neutropenia
/ blood
Phenotype
Respiratory Distress Syndrome, Newborn
/ blood
Retinopathy of Prematurity
/ blood
Retrospective Studies
Risk Factors
Sepsis
/ blood
ABO antigens
ABO blood group
endothelial injury
neonatal disease
neonatal neutropenia
neonatal sepsis
Journal
Journal of neonatal-perinatal medicine
ISSN: 1878-4429
Titre abrégé: J Neonatal Perinatal Med
Pays: Netherlands
ID NLM: 101468335
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
24
10
2018
medline:
26
9
2019
entrez:
24
10
2018
Statut:
ppublish
Résumé
Numerous studies have examined the association between ABO blood groups and adult disease states, but very few have studied the neonatal population. The objective of this study was to determine the relationship between AB blood group and the occurrence of common neonatal disorders such as neutropenia at birth, sepsis, respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), and patent ductus arteriosus (PDA) compared to all other blood groups. We performed a retrospective review on 3,981 infants born at 22 0/7 to 42 6/7 weeks' gestational age and compared the relative risk of neonatal diseases in infants with AB blood group to that of infants with all other blood groups (A, B, and O). When compared to all other blood groups, AB infants demonstrated an increased risk for developing negative clinical outcomes. AB blood group was significantly associated with a 14-89% increased risk of neutropenia at birth, sepsis, RDS, and ROP. Risks for IVH and PDA were not significant. We hypothesize that the phenotypic expression of A and B antigens, rather than the antigens themselves, in the AB group may reveal an enhanced susceptibility to injury at the endothelial level resulting in an increased risk for disease development.
Sections du résumé
BACKGROUND
BACKGROUND
Numerous studies have examined the association between ABO blood groups and adult disease states, but very few have studied the neonatal population. The objective of this study was to determine the relationship between AB blood group and the occurrence of common neonatal disorders such as neutropenia at birth, sepsis, respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), and patent ductus arteriosus (PDA) compared to all other blood groups.
METHODS
METHODS
We performed a retrospective review on 3,981 infants born at 22 0/7 to 42 6/7 weeks' gestational age and compared the relative risk of neonatal diseases in infants with AB blood group to that of infants with all other blood groups (A, B, and O).
RESULTS
RESULTS
When compared to all other blood groups, AB infants demonstrated an increased risk for developing negative clinical outcomes. AB blood group was significantly associated with a 14-89% increased risk of neutropenia at birth, sepsis, RDS, and ROP. Risks for IVH and PDA were not significant.
CONCLUSION
CONCLUSIONS
We hypothesize that the phenotypic expression of A and B antigens, rather than the antigens themselves, in the AB group may reveal an enhanced susceptibility to injury at the endothelial level resulting in an increased risk for disease development.
Identifiants
pubmed: 30347622
pii: NPM17115
doi: 10.3233/NPM-17115
doi:
Substances chimiques
ABO Blood-Group System
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM