DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway.
Adenocarcinoma
/ genetics
Animals
Biomarkers, Tumor
Cell Line, Tumor
DNA Copy Number Variations
Disease Models, Animal
Female
Humans
Immunohistochemistry
Intestinal Neoplasms
/ genetics
Intestine, Small
/ pathology
Male
Mice
Mutation
Protein Binding
Protein Interaction Domains and Motifs
Receptor, ErbB-2
/ chemistry
Signal Transduction
Exome Sequencing
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
11
05
2018
revised:
13
09
2018
accepted:
18
10
2018
pubmed:
26
10
2018
medline:
28
2
2020
entrez:
25
10
2018
Statut:
ppublish
Résumé
Little is known about the genetic alterations characteristic of small bowel adenocarcinoma (SBA). Our purpose was to identify targetable alterations and develop experimental models of this disease. WES identified somatic mutations in 4 canonical pathways (WNT, ERBB2, STAT3, and chromatin remodeling), which were validated in the TES cohort. Although The
Identifiants
pubmed: 30352910
pii: 1078-0432.CCR-18-1480
doi: 10.1158/1078-0432.CCR-18-1480
pmc: PMC6335167
mid: NIHMS1510533
doi:
Substances chimiques
Biomarkers, Tumor
0
ERBB2 protein, human
EC 2.7.10.1
Receptor, ErbB-2
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
641-651Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Informations de copyright
©2018 American Association for Cancer Research.
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