Peritoneal dialysis after kidney transplant failure: a nationwide matched cohort study from the French Language Peritoneal Dialysis Registry (RDPLF).
Adolescent
Adult
Aged
Aged, 80 and over
Female
Follow-Up Studies
France
/ epidemiology
Humans
Incidence
Kidney Failure, Chronic
/ surgery
Kidney Transplantation
/ adverse effects
Language
Male
Middle Aged
Peritoneal Dialysis
/ methods
Peritonitis
/ epidemiology
Postoperative Complications
Registries
Retrospective Studies
Survival Rate
/ trends
Young Adult
epidemiology
peritoneal dialysis
transplant failure
transplantation
Journal
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
ISSN: 1460-2385
Titre abrégé: Nephrol Dial Transplant
Pays: England
ID NLM: 8706402
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
received:
08
04
2017
pubmed:
26
10
2018
medline:
17
3
2020
entrez:
26
10
2018
Statut:
ppublish
Résumé
Failed kidney transplant is becoming a frequent cause of dialysis initiation. Although studies have shown no difference between peritoneal dialysis (PD) and haemodialysis (HD) in terms of patients and technique survival, PD remains quite rarely used in this condition. Studies in larger multicentre matched cohorts are missing. We conducted a retrospective study about 328 patients registered in the French Language Peritoneal Dialysis Registry (RDPLF) who started PD after kidney transplant failure (Tx group) between January 2002 and December 2012 who were compared with 656 matched never-transplanted patients having started PD during the same period (control group). Patients and PD technique survival as well as peritonitis episodes were analysed. Over the study period, patients' survival was similar between the two groups (P = 0.34). The mean time on PD was significantly shorter for patients in the Tx group [17 months (range 14-20)] compared with the control group [21 months (range 19-23)] (P = 0.003). The main cause of transfer to HD was for both group adequacy and/or ultrafiltration failure. Peritonitis rates were similar in the two groups: 43.6% (n = 143) versus 40.1% (n = 263) in the Tx and control group, respectively (P = 0.3). In multivariate Cox analysis, kidney transplant failure (P < 0.0001), younger age (P = 0.02) and male gender (P = 0.01) were associated with a higher risk of transfer to HD. Using multivariate competing risk analysis, kidney transplant failure was again observed as a predictive factor (P < 0.0001), but not age and gender. The only other significant predictive factor observed was peritonitis episodes experienced during PD treatment (P = 0.002). Comparing the Tx and control groups, we report similar patient survival and peritonitis rates but a higher PD technique failure in the Tx group.
Sections du résumé
BACKGROUND
Failed kidney transplant is becoming a frequent cause of dialysis initiation. Although studies have shown no difference between peritoneal dialysis (PD) and haemodialysis (HD) in terms of patients and technique survival, PD remains quite rarely used in this condition. Studies in larger multicentre matched cohorts are missing.
METHODS
We conducted a retrospective study about 328 patients registered in the French Language Peritoneal Dialysis Registry (RDPLF) who started PD after kidney transplant failure (Tx group) between January 2002 and December 2012 who were compared with 656 matched never-transplanted patients having started PD during the same period (control group). Patients and PD technique survival as well as peritonitis episodes were analysed.
RESULTS
Over the study period, patients' survival was similar between the two groups (P = 0.34). The mean time on PD was significantly shorter for patients in the Tx group [17 months (range 14-20)] compared with the control group [21 months (range 19-23)] (P = 0.003). The main cause of transfer to HD was for both group adequacy and/or ultrafiltration failure. Peritonitis rates were similar in the two groups: 43.6% (n = 143) versus 40.1% (n = 263) in the Tx and control group, respectively (P = 0.3). In multivariate Cox analysis, kidney transplant failure (P < 0.0001), younger age (P = 0.02) and male gender (P = 0.01) were associated with a higher risk of transfer to HD. Using multivariate competing risk analysis, kidney transplant failure was again observed as a predictive factor (P < 0.0001), but not age and gender. The only other significant predictive factor observed was peritonitis episodes experienced during PD treatment (P = 0.002).
CONCLUSIONS
Comparing the Tx and control groups, we report similar patient survival and peritonitis rates but a higher PD technique failure in the Tx group.
Identifiants
pubmed: 30358867
pii: 5144428
doi: 10.1093/ndt/gfy290
doi:
Types de publication
Comparative Study
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
858-863Informations de copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.