Virtual memory CD8 T cells expanded by helminth infection confer broad protection against bacterial infection.
Animals
Bystander Effect
CD8-Positive T-Lymphocytes
/ immunology
Immunity, Innate
Immunization
Immunologic Memory
Immunomodulation
Interleukin-4
/ genetics
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Knockout
Natural Killer T-Cells
/ immunology
Nematospiroides dubius
/ immunology
Strongylida Infections
/ immunology
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
31
03
2018
accepted:
30
09
2018
revised:
24
09
2018
pubmed:
27
10
2018
medline:
15
5
2019
entrez:
27
10
2018
Statut:
ppublish
Résumé
Epidemiological data and animal studies suggest that helminth infection exerts potent immunomodulatory effects that dampen host immunity against unrelated pathogens. Despite this notion, we unexpectedly discovered that prior helminth infection resulted in enhanced protection against subsequent systemic and enteric bacterial infection. A population of virtual memory CD8 T (CD8 T
Identifiants
pubmed: 30361537
doi: 10.1038/s41385-018-0100-x
pii: S1933-0219(22)00372-5
pmc: PMC6301144
mid: NIHMS1508707
doi:
Substances chimiques
Interleukin-4
207137-56-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
258-264Subventions
Organisme : NIAID NIH HHS
ID : R01 AI061577
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI076479
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI061577
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI104788
Pays : United States
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