Scintigraphic liver function and transient elastography in the assessment of patients with resectable hepatocellular carcinoma.
Aged
Aniline Compounds
Carcinoma, Hepatocellular
/ diagnostic imaging
Elasticity Imaging Techniques
Female
Glycine
Humans
Imino Acids
Liver Function Tests
Liver Neoplasms
/ diagnostic imaging
Male
Middle Aged
Organotechnetium Compounds
Postoperative Complications
Radionuclide Imaging
/ methods
Radiopharmaceuticals
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Journal
HPB : the official journal of the International Hepato Pancreato Biliary Association
ISSN: 1477-2574
Titre abrégé: HPB (Oxford)
Pays: England
ID NLM: 100900921
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
09
04
2018
revised:
16
09
2018
accepted:
27
09
2018
pubmed:
28
10
2018
medline:
9
4
2020
entrez:
28
10
2018
Statut:
ppublish
Résumé
Hepatobiliary scintigraphy (HBS) is used to quantify total and regional liver function. Transient elastography (TE) provides a non-invasive alternative to percutaneous biopsy to assess liver fibrosis and cirrhosis. This study aims to determine the correlation between HBS and histopathology of liver parenchyma, and to compare these with TE in patients with resectable hepatocellular carcinoma (HCC). Patients who underwent surgery for HCC between 2000 and 2016 after preoperative HBS were included. Non-tumorous liver tissue was evaluated for inflammation, steatosis, ballooning, siderosis and fibrosis. Correlation analysis was performed between HBS results and histopathological scoring. These were also compared with TE and surgical outcomes. 71 patients underwent preoperative HBS of whom 24 also had TE. HBS correlated with portal and lobular inflammation as well as fibrosis. TE correlated with portal and lobular inflammation, ballooning and fibrosis. A significant correlation was found between HBS and TE. No association was found with overall postoperative morbidity and mortality. HBS and TE show a moderate to strong correlation. HBS and TE share discriminatory features of histopathological scoring and show a weak to moderate correlation with hepatic inflammation and fibrosis.
Sections du résumé
BACKGROUND
Hepatobiliary scintigraphy (HBS) is used to quantify total and regional liver function. Transient elastography (TE) provides a non-invasive alternative to percutaneous biopsy to assess liver fibrosis and cirrhosis. This study aims to determine the correlation between HBS and histopathology of liver parenchyma, and to compare these with TE in patients with resectable hepatocellular carcinoma (HCC).
METHODS
Patients who underwent surgery for HCC between 2000 and 2016 after preoperative HBS were included. Non-tumorous liver tissue was evaluated for inflammation, steatosis, ballooning, siderosis and fibrosis. Correlation analysis was performed between HBS results and histopathological scoring. These were also compared with TE and surgical outcomes.
RESULTS
71 patients underwent preoperative HBS of whom 24 also had TE. HBS correlated with portal and lobular inflammation as well as fibrosis. TE correlated with portal and lobular inflammation, ballooning and fibrosis. A significant correlation was found between HBS and TE. No association was found with overall postoperative morbidity and mortality.
CONCLUSION
HBS and TE show a moderate to strong correlation. HBS and TE share discriminatory features of histopathological scoring and show a weak to moderate correlation with hepatic inflammation and fibrosis.
Identifiants
pubmed: 30366883
pii: S1365-182X(18)34471-X
doi: 10.1016/j.hpb.2018.09.021
pii:
doi:
Substances chimiques
Aniline Compounds
0
Imino Acids
0
Organotechnetium Compounds
0
Radiopharmaceuticals
0
technetium Tc 99m mebrofenin
F2NQ468L52
Glycine
TE7660XO1C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
626-635Informations de copyright
Copyright © 2018 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.