Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

Anti-Bacterial Agents / metabolism Bacterial Proteins / genetics Carbapenems / metabolism Cohort Studies Computational Biology / methods Drug Resistance, Multiple, Bacterial / genetics Gene Expression Gene Library Genome, Bacterial Humans Klebsiella Infections / drug therapy Klebsiella pneumoniae / drug effects Microbial Sensitivity Tests Phenotype Polymorphism, Single Nucleotide Whole Genome Sequencing / instrumentation beta-Lactamases / genetics
Illumina WGS antibiotic resistance antimicrobial resistance

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
01 2019
Historique:
received: 06 09 2018
accepted: 22 10 2018
pubmed: 31 10 2018
medline: 15 1 2020
entrez: 31 10 2018
Statut: epublish

Résumé

Standard antimicrobial susceptibility testing (AST) approaches lead to delays in the selection of optimal antimicrobial therapy. Here, we sought to determine the accuracy of antimicrobial resistance (AMR) determinants identified by Nanopore whole-genome sequencing in predicting AST results. Using a cohort of 40 clinical isolates (21 carbapenemase-producing carbapenem-resistant

Identifiants

DOI: 10.1128/AAC.01923-18 PMID: 30373801 PMC: PMC6325187
pubmed: 30373801
pii: AAC.01923-18
doi: 10.1128/AAC.01923-18
pmc: PMC6325187
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Bacterial Proteins 0
Carbapenems 0
beta-Lactamases EC 3.5.2.6
carbapenemase EC 3.5.2.6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : K23 AI127935
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG006677
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG009190
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI130608
Pays : United States
Organisme : CIHR
Pays : Canada

Informations de copyright

Copyright © 2018 American Society for Microbiology.

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Auteurs

Pranita D Tamma (PD)

Johns Hopkins University School of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Baltimore, Maryland, USA.

Yunfan Fan (Y)

Johns Hopkins University, Department of Biomedical Engineering, Baltimore, Maryland, USA.

Yehudit Bergman (Y)

Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, Maryland, USA.

Geo Pertea (G)

Johns Hopkins University, Department of Computer Science, Baltimore, Maryland, USA.

Abida Q Kazmi (AQ)

Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, Maryland, USA.

Shawna Lewis (S)

Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, Maryland, USA.

Karen C Carroll (KC)

Johns Hopkins University School of Medicine, Department of Pathology, Division of Medical Microbiology, Baltimore, Maryland, USA.

Michael C Schatz (MC)

Johns Hopkins University, Department of Computer Science, Baltimore, Maryland, USA.
Johns Hopkins University, Department of Biology, Baltimore, Maryland, USA.

Winston Timp (W)

Johns Hopkins University, Department of Biomedical Engineering, Baltimore, Maryland, USA.
ORCID: 0000-0003-2083-6027

Patricia J Simner (PJ)

Johns Hopkins University School of Medicine, Department of Pathology, Division of Medical Microbiology, Baltimore, Maryland, USA psimner1@jhmi.edu.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Carbapénèmes › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Multirésistance aux médicaments › Multirésistance bactérienne aux médicaments › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Banque de gènes › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Infections à Klebsiella › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Klebsiella › Klebsiella pneumoniae › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Applying Rapid Whole-Genome Sequencing To...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › bêta-Lactamases › Applying Rapid Whole-Genome Sequencing To...