Incidental thoracic findings in computed tomography scans before transcatheter aortic valve implantation.


Journal

Interactive cardiovascular and thoracic surgery
ISSN: 1569-9285
Titre abrégé: Interact Cardiovasc Thorac Surg
Pays: England
ID NLM: 101158399

Informations de publication

Date de publication:
01 04 2019
Historique:
received: 20 06 2018
revised: 10 09 2018
accepted: 16 09 2018
pubmed: 1 11 2018
medline: 13 11 2019
entrez: 1 11 2018
Statut: ppublish

Résumé

Preoperative computed tomography (CT) scans for transcatheter aortic valve implantation (TAVI) are used routinely. In elderly high-risk patients, incidental radiographic findings are frequently reported. The aim of this study was to investigate the impact of auxiliary findings on the patients' mid-term survival, which might affect the treatment strategy. Between March 2011 and April 2016, all radiological reports of contrast-enhanced CT scans of 976 patients scheduled for TAVI were analysed retrospectively for incidental thoracic findings including solitary pulmonary nodules (SPN) and thoracic lymphadenopathy (LAP). The minimum follow-up period was 1 year after TAVI. The median age of all patients was 79 years; 51.9% (n = 507) were women. Approximately 37% (n = 361) of patients showed 1 of the determined findings. An SPN ≥5 mm was diagnosed in 16.4% (n = 160) of patients. Four of them developed lung cancer and 2 nodules were identified as metastases during follow-up. In addition, 12% (n = 117) of the patients had thoracic LAP. Whereas SPN had no significant effect on the overall survival rate, evidence of LAP turned out to be a statistically significant factor regarding 4-year survival (P = 0.001; hazard ratio 1.66; 95% confidence internal 1.19-2.31). SPN ≥5 mm were detected in 16.4% of patients scheduled for TAVI. Nevertheless, the incidence of lung cancer was low and the effect on survival in this high-risk group of patients was statistically not significant. In contrast, thoracic LAP had a significant negative effect on survival. It needs to be proven if the outcome of this cohort can be enhanced by further diagnostics and therapy.

Identifiants

pubmed: 30380069
pii: 5149802
doi: 10.1093/icvts/ivy299
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

559-565

Informations de copyright

© The Author(s) 2018. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Auteurs

Till Markowiak (T)

Department of Thoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.

Andreas Holzamer (A)

Department of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.

Michael Hilker (M)

Department of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.

Benedikt Pregler (B)

Department of Radiology, University Medical Center Regensburg, Regensburg, Germany.

Kurt Debl (K)

Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.

Hans-Stefan Hofmann (HS)

Department of Thoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.

Michael Ried (M)

Department of Thoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.

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Classifications MeSH