Timescales of developmental toxicity impacting on research and needs for intervention.
Animals
Big Data
Computational Chemistry
/ methods
Congresses as Topic
Disease Models, Animal
Ecotoxicology
/ methods
Endocrine Disruptors
/ adverse effects
Environmental Exposure
/ adverse effects
Environmental Medicine
/ methods
Epigenesis, Genetic
/ drug effects
Epigenomics
/ methods
Female
Fetal Development
/ drug effects
Humans
Metabolomics
/ methods
Pregnancy
Prenatal Exposure Delayed Effects
/ diagnosis
Research Design
Risk Assessment
/ methods
Time Factors
Journal
Basic & clinical pharmacology & toxicology
ISSN: 1742-7843
Titre abrégé: Basic Clin Pharmacol Toxicol
Pays: England
ID NLM: 101208422
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
19
09
2018
accepted:
29
10
2018
pubmed:
6
11
2018
medline:
28
1
2020
entrez:
3
11
2018
Statut:
ppublish
Résumé
Much progress has happened in understanding developmental vulnerability to preventable environmental hazards. Along with the improved insight, the perspective has widened, and developmental toxicity now involves latent effects that can result in delayed adverse effects in adults or at old age and additional effects that can be transgenerationally transferred to future generations. Although epidemiology and toxicology to an increasing degree are exploring the adverse effects from developmental exposures in human beings, the improved documentation has resulted in little progress in protection, and few environmental chemicals are currently regulated to protect against developmental toxicity, whether it be neurotoxicity, endocrine disruption or other adverse outcome. The desire to obtain a high degree of certainty and verification of the evidence used for decision-making must be weighed against the costs and necessary duration of research, as well as the long-term costs to human health because of delayed protection of vulnerable early-life stages of human development and, possibly, future generations. Although two-generation toxicology tests may be useful for initial test purposes, other rapidly emerging tools need to be seriously considered from computational chemistry and metabolomics to CLARITY-BPA-type designs, big data and population record linkage approaches that will allow efficient generation of new insight; epigenetic mechanisms may necessitate a set of additional regulatory tests to reveal such effects. As reflected by the Prenatal Programming and Toxicity (PPTOX) VI conference, the current scientific understanding and the timescales involved require an intensified approach to protect against preventable adverse health effects that can harm the next generation and generations to come. While further research is needed, the main emphasis should be on research translation and timely public health intervention to avoid serious, irreversible and perhaps transgenerational harm.
Identifiants
pubmed: 30387920
doi: 10.1111/bcpt.13162
pmc: PMC6497561
mid: NIHMS1002905
doi:
Substances chimiques
Endocrine Disruptors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
70-80Subventions
Organisme : STEEP Superfund Center
ID : P42ES027706
Organisme : NIEHS NIH HHS
ID : R13 ES029385
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES026596
Pays : United States
Organisme : NIEHS NIH HHS
ID : R13ES029385
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES027706
Pays : United States
Informations de copyright
© 2018 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
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