Pulmonary and other health effects of electronic cigarette use among adult smokers participating in a randomized controlled smoking reduction trial.
Adult
Blood Pressure
Body Weight
Breath Tests
Carbon Monoxide
/ analysis
Cigarette Smoking
/ physiopathology
Counseling
Female
Forced Expiratory Volume
Heart Rate
Humans
Lung
/ physiopathology
Male
Maximal Midexpiratory Flow Rate
Middle Aged
Respiratory Function Tests
Smoking Reduction
/ methods
Spirometry
Vaping
Vital Capacity
Electronic cigarettes
Health effects
Lung function
Smoking reduction
Journal
Addictive behaviors
ISSN: 1873-6327
Titre abrégé: Addict Behav
Pays: England
ID NLM: 7603486
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
18
04
2018
revised:
01
10
2018
accepted:
28
10
2018
pubmed:
6
11
2018
medline:
17
6
2020
entrez:
6
11
2018
Statut:
ppublish
Résumé
There is limited evidence about the effects of dual electronic cigarette (e-cig) and combustible cigarette use on lung health or other health outcomes. Studies that have evaluated these outcomes have not included estimates of e-cig or cigarette exposure in the analyses. Data analyzed were from 263 smokers participating in a randomized controlled trial designed to encourage participants to reduce their combustible cigarette use by substituting with an e-cig or a non-electronic cigarette substitute (cig-sub). t-tests were used to evaluate changes from baseline at 1 month and 3 months in lung function, blood pressure, pulse, exhaled carbon monoxide, and weight. Linear mixed effects models were used to test associations between health outcomes and study product group, including exposure to the study products (e-cig and cig-sub times used and days used in the past 7 days) and cigarettes per day (CPD). There were few significant differences between the groups for lung function indices at any time point in the unadjusted analyses. There were significant reductions in diastolic blood pressure and pulse at 1 month in the unadjusted analyses for those in the e-cig group compared to the cig-sub group. CPD decreased significantly more for the e-cig group than for the cig-sub group at both time points. There were no significant associations between any measured health outcomes and group in the linear mixed effects models. E-cig use did not contribute to significant changes in health outcome markers as compared with use of a non-electronic cig-sub.
Sections du résumé
BACKGROUND
There is limited evidence about the effects of dual electronic cigarette (e-cig) and combustible cigarette use on lung health or other health outcomes. Studies that have evaluated these outcomes have not included estimates of e-cig or cigarette exposure in the analyses.
MATERIALS AND METHODS
Data analyzed were from 263 smokers participating in a randomized controlled trial designed to encourage participants to reduce their combustible cigarette use by substituting with an e-cig or a non-electronic cigarette substitute (cig-sub). t-tests were used to evaluate changes from baseline at 1 month and 3 months in lung function, blood pressure, pulse, exhaled carbon monoxide, and weight. Linear mixed effects models were used to test associations between health outcomes and study product group, including exposure to the study products (e-cig and cig-sub times used and days used in the past 7 days) and cigarettes per day (CPD).
RESULTS
There were few significant differences between the groups for lung function indices at any time point in the unadjusted analyses. There were significant reductions in diastolic blood pressure and pulse at 1 month in the unadjusted analyses for those in the e-cig group compared to the cig-sub group. CPD decreased significantly more for the e-cig group than for the cig-sub group at both time points. There were no significant associations between any measured health outcomes and group in the linear mixed effects models.
CONCLUSION
E-cig use did not contribute to significant changes in health outcome markers as compared with use of a non-electronic cig-sub.
Identifiants
pubmed: 30393015
pii: S0306-4603(18)31250-4
doi: 10.1016/j.addbeh.2018.10.041
pmc: PMC6358505
mid: NIHMS1511741
pii:
doi:
Substances chimiques
Carbon Monoxide
7U1EE4V452
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-101Subventions
Organisme : NIDA NIH HHS
ID : P50 DA036105
Pays : United States
Organisme : NIDA NIH HHS
ID : U54 DA036105
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000058
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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