Cell Surface Notch Ligand DLL3 is a Therapeutic Target in Isocitrate Dehydrogenase-mutant Glioma.
Antibodies, Monoclonal, Humanized
/ genetics
Benzodiazepinones
/ therapeutic use
Brain
/ pathology
DNA Methylation
/ genetics
Female
Gene Expression Regulation, Neoplastic
/ drug effects
Genotype
Glioma
/ drug therapy
Humans
Immunoconjugates
/ genetics
Intracellular Signaling Peptides and Proteins
/ genetics
Isocitrate Dehydrogenase
/ genetics
Ligands
Male
Membrane Proteins
/ genetics
Molecular Targeted Therapy
Mutation
Neoplasm Recurrence, Local
/ drug therapy
RNA
/ genetics
Receptors, Notch
/ genetics
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
18
07
2018
revised:
30
10
2018
accepted:
01
11
2018
pubmed:
7
11
2018
medline:
21
4
2020
entrez:
7
11
2018
Statut:
ppublish
Résumé
Isocitrate dehydrogenase ( We evaluated Compared to DLL3 is selectively and homogeneously expressed in
Identifiants
pubmed: 30397180
pii: 1078-0432.CCR-18-2312
doi: 10.1158/1078-0432.CCR-18-2312
pmc: PMC7365589
mid: NIHMS1594188
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
Benzodiazepinones
0
DLL3 protein, human
0
Immunoconjugates
0
Intracellular Signaling Peptides and Proteins
0
Ligands
0
Membrane Proteins
0
Receptors, Notch
0
rovalpituzumab tesirine
0
RNA
63231-63-0
Isocitrate Dehydrogenase
EC 1.1.1.41
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1261-1271Subventions
Organisme : NCI NIH HHS
ID : P30 CA016087
Pays : United States
Organisme : NIH HHS
ID : S10 OD018338
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102665
Pays : United States
Organisme : NIH HHS
ID : S10 OD010584
Pays : United States
Organisme : NINDS NIH HHS
ID : R03 NS087349
Pays : United States
Informations de copyright
©2018 American Association for Cancer Research.
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