Pharmacological Inhibition of Serine Palmitoyl Transferase and Sphingosine Kinase-1/-2 Inhibits Merkel Cell Carcinoma Cell Proliferation.
Carcinoma, Merkel Cell
/ drug therapy
Cell Count
Cell Line, Tumor
Cell Proliferation
/ drug effects
Fatty Acids, Monounsaturated
/ pharmacology
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Immunosuppressive Agents
/ pharmacology
Merkel cell polyomavirus
/ immunology
Phosphotransferases (Alcohol Group Acceptor)
/ antagonists & inhibitors
Polyomavirus Infections
/ drug therapy
RNA, Neoplasm
/ genetics
Serine C-Palmitoyltransferase
/ antagonists & inhibitors
Skin Neoplasms
/ drug therapy
Tumor Virus Infections
/ drug therapy
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
12
06
2018
revised:
21
09
2018
accepted:
23
10
2018
pubmed:
7
11
2018
medline:
3
4
2020
entrez:
7
11
2018
Statut:
ppublish
Résumé
The majority of Merkel cell carcinoma, a highly aggressive neuroendocrine cancer of the skin, is associated with Merkel cell polyomavirus infection. Polyomavirus binding, internalization, and infection are mediated by glycosphingolipids. Besides receptor function, bioactive sphingolipids are increasingly recognized as potent regulators of several hallmarks of cancer. Merkel cell polyomavirus
Identifiants
pubmed: 30399362
pii: S0022-202X(18)32786-6
doi: 10.1016/j.jid.2018.10.024
pii:
doi:
Substances chimiques
Fatty Acids, Monounsaturated
0
Immunosuppressive Agents
0
RNA, Neoplasm
0
Serine C-Palmitoyltransferase
EC 2.3.1.50
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
sphingosine kinase
EC 2.7.1.-
thermozymocidin
YRM4E8R9ST
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
807-817Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.