HIV-1 infection renders brain vascular pericytes susceptible to the extracellular glutamate.

Astrocytes / drug effects Ataxia Telangiectasia Mutated Proteins / antagonists & inhibitors Benzamides / pharmacology Brain / metabolism Chromones / pharmacology DNA / genetics DNA Damage DNA-Activated Protein Kinase / antagonists & inhibitors Gene Expression Regulation Glutamic Acid / pharmacology HIV-1 / drug effects Histones / agonists Host-Pathogen Interactions / genetics Humans Interleukin-1beta / pharmacology Morpholines / pharmacology Pericytes / drug effects Poly(ADP-ribose) Polymerases / genetics Primary Cell Culture Pyrones / pharmacology Signal Transduction Tumor Necrosis Factor-alpha / pharmacology Virus Activation / drug effects Virus Latency / drug effects Virus Replication / drug effects
Astrocytes Central memory T cells DNA damage response Glutamate HIV latency Pericytes

Journal

Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123

Informations de publication

Date de publication:
02 2019
Historique:
received: 01 08 2018
accepted: 25 10 2018
revised: 28 09 2018
pubmed: 8 11 2018
medline: 8 9 2020
entrez: 8 11 2018
Statut: ppublish

Résumé

Reduced pericytes' coverage of endothelium in the brain is one of the structural changes leading to breach of the blood-brain barrier during HIV infection. We previously showed in central memory T (T

Identifiants

DOI: 10.1007/s13365-018-0693-6 PMID: 30402824 PMC: PMC6417930
pubmed: 30402824
doi: 10.1007/s13365-018-0693-6
pii: 10.1007/s13365-018-0693-6
pmc: PMC6417930
mid: NIHMS1000853
doi:

Substances chimiques

2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one 0
8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one 0
Benzamides 0
Chromones 0
H2AX protein, human 0
Histones 0
IL1B protein, human 0
Interleukin-1beta 0
Morpholines 0
Pyrones 0
Tumor Necrosis Factor-alpha 0
Glutamic Acid 3KX376GY7L
3-aminobenzamide 8J365YF1YH
DNA 9007-49-2
Poly(ADP-ribose) Polymerases EC 2.4.2.30
ATM protein, human EC 2.7.11.1
Ataxia Telangiectasia Mutated Proteins EC 2.7.11.1
DNA-Activated Protein Kinase EC 2.7.11.1
PRKDC protein, human EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

114-126

Subventions

Organisme : NIAID NIH HHS
ID : R21 AI131961
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS054578
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS066801
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI078498
Pays : United States

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Auteurs

Dorota Piekna-Przybylska (D)

Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA. dorota_piekna@urmc.rochester.edu.
ORCID: 0000-0001-7328-9755

Kavyasri Nagumotu (K)

Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.

Danielle M Reid (DM)

Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.

Sanjay B Maggirwar (SB)

Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.

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Classifications MeSH

questionsmedicales.fr › Cellules › Névroglie › Astrocytes › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Protéines mutées dans l'ataxie-télangiectasie › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › DNA-activated protein kinase › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Monokines › Interleukine-1 › Interleukine-1 bêta › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Oxazines › Morpholines › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Structures de l'embryon › Feuillets embryonnaires › Mésoderme › Péricytes › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Poly(ADP-ribose) polymerases › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Culture de cellules primaires › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrannes › Pyrones › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Activation virale › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Latence virale › HIV-1 infection renders brain vascular...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › HIV-1 infection renders brain vascular...