NMR Characterization of Long-Range Contacts in Intrinsically Disordered Proteins from Paramagnetic Relaxation Enhancement in

Carbon Isotopes Intrinsically Disordered Proteins / analysis Mutation Nuclear Magnetic Resonance, Biomolecular Osteopontin / chemistry
NMR spectroscopy carbon magnetic properties proteins structure elucidation

Journal

Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360

Informations de publication

Date de publication:
01 02 2019
Historique:
received: 12 09 2018
pubmed: 9 11 2018
medline: 28 11 2019
entrez: 9 11 2018
Statut: ppublish

Résumé

Intrinsically disordered proteins (IDPs) carry out many biological functions. They lack a stable 3D structure and are able to adopt many different conformations in dynamic equilibrium. The interplay between local dynamics and global rearrangements is key for their function. A widely used experimental NMR spectroscopy approach to study long-range contacts in IDPs exploits paramagnetic effects, and

Identifiants

DOI: 10.1002/cbic.201800539 PMID: 30407719
pubmed: 30407719
doi: 10.1002/cbic.201800539
doi:

Substances chimiques

Carbon Isotopes 0
Intrinsically Disordered Proteins 0
Osteopontin 106441-73-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

335-339

Informations de copyright

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Auteurs

Borja Mateos (B)

Department of Structural and Computational Biology, Max F. Perutz Laboratories, Vienna Biocenter Campus 5, 1030, Vienna, Austria.
ORCID: 0000-0002-0310-4943

Robert Konrat (R)

Department of Structural and Computational Biology, Max F. Perutz Laboratories, Vienna Biocenter Campus 5, 1030, Vienna, Austria.
ORCID: 0000-0001-6489-4080

Roberta Pierattelli (R)

CERM and Department of Chemistry "Ugo Schiff", University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Florence, Italy.
ORCID: 0000-0001-7755-0885

Isabella C Felli (IC)

CERM and Department of Chemistry "Ugo Schiff", University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Florence, Italy.
ORCID: 0000-0002-6018-9090

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Isotopes du carbone › NMR Characterization of Long-Range Contacts in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines intrinsèquement désordonnées › NMR Characterization of Long-Range Contacts in...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › NMR Characterization of Long-Range Contacts in...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Résonance magnétique nucléaire biomoléculaire › NMR Characterization of Long-Range Contacts in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Ostéopontine › NMR Characterization of Long-Range Contacts in...