Integrin binding site within the gC1q domain orchestrates EMILIN-1-induced lymphangiogenesis.

Animals Binding Sites Cell Line Humans Integrin alpha4 / chemistry Integrins / chemistry Lymphangiogenesis Membrane Glycoproteins / chemistry Mice Mice, Transgenic Mutation Protein Domains
Extracellular matrix Integrin Lymph node metastasis Lymphangiogenesis Lymphatic endothelial cells

Journal

Matrix biology : journal of the International Society for Matrix Biology
ISSN: 1569-1802
Titre abrégé: Matrix Biol
Pays: Netherlands
ID NLM: 9432592

Informations de publication

Date de publication:
08 2019
Historique:
received: 06 08 2018
revised: 10 09 2018
accepted: 24 10 2018
pubmed: 9 11 2018
medline: 12 5 2020
entrez: 9 11 2018
Statut: ppublish

Résumé

Lymphatic vessels (LVs) play a pivotal role in the control of tissue homeostasis and also have emerged as important regulators of immunity, inflammation and tumor metastasis. EMILIN-1 is the first ECM protein identified as a structural modulator of the growth and maintenance of LV; accordingly, Emilin1

Identifiants

DOI: 10.1016/j.matbio.2018.10.006 PMID: 30408617
pubmed: 30408617
pii: S0945-053X(18)30344-5
doi: 10.1016/j.matbio.2018.10.006
pii:
doi:

Substances chimiques

Integrins 0
Membrane Glycoproteins 0
elastin microfibril interface located protein 0
integrin alpha 9 beta 1 0
Integrin alpha4 143198-26-9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

34-49

Informations de copyright

Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Alessandra Capuano (A)

Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.

Eliana Pivetta (E)

Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.

Francesca Baldissera (F)

Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.

Giulia Bosisio (G)

Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.

Bruna Wassermann (B)

Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.

Francesco Bucciotti (F)

Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.

Alfonso Colombatti (A)

Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.

Patrizia Sabatelli (P)

Institute of Molecular Genetics, National Research Council of Italy, Bologna, Italy.

Roberto Doliana (R)

Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy. Electronic address: rdoliana@cro.it.

Paola Spessotto (P)

Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy. Electronic address: pspessotto@cro.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Integrin binding site within the gC1q domain...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Integrin binding site within the gC1q domain...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Integrin binding site within the gC1q domain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Integrin binding site within the gC1q domain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Intégrines › Intégrines alpha › Intégrine alpha4 › Integrin binding site within the gC1q domain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Intégrines › Integrin binding site within the gC1q domain...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Lymphangiogenèse › Integrin binding site within the gC1q domain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Integrin binding site within the gC1q domain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Integrin binding site within the gC1q domain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Integrin binding site within the gC1q domain...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Integrin binding site within the gC1q domain...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Integrin binding site within the gC1q domain...