Prevalence of
Adult
Arrhythmogenic Right Ventricular Dysplasia
/ diagnosis
Biopsy
Female
Fluorodeoxyglucose F18
/ pharmacology
Follow-Up Studies
Humans
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Myocarditis
/ complications
Myocardium
/ pathology
Positron-Emission Tomography
/ methods
Prevalence
Prognosis
Radiopharmaceuticals
/ pharmacology
Retrospective Studies
Risk Factors
Survival Rate
/ trends
United Kingdom
/ epidemiology
(18)F-fluorodeoxyglucose
Arrhythmogenic right ventricular cardiomyopathy
Cardiac magnetic resonance imaging
Myocarditis
Positron emission tomography
Journal
International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
23
07
2018
revised:
25
09
2018
accepted:
23
10
2018
pubmed:
10
11
2018
medline:
7
1
2020
entrez:
10
11
2018
Statut:
ppublish
Résumé
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable heart muscle disease that causes sudden cardiac death in the young. Inflammatory myocardial infiltrates have been described at autopsy and on biopsy, but there are few data on the presence of myocarditis in living patients with ARVC using non-invasive imaging techniques. FDG-PET is a validated technique for detecting myocardial inflammation in clinically suspected myocarditis. We aimed to determine the prevalence of myocardial inflammation in patients with ARVC using We performed a retrospective analysis of a single centre cohort of patients with ARVC referred for FDG-PET scans between 2012 and 2017 for investigation of symptoms or suspected device infection. Sixteen patients (12 male; age 42 ± 13 years) with a definite diagnosis of ARVC were identified. Seven had positive FDG-PET scans, two of whom had cardiac sarcoidosis on endomyocardial biopsy. Of the remaining five, two carried pathogenic desmoplakin mutations. FDG uptake was found in the left ventricular myocardium in all cases. One patient also had right ventricular uptake. In this exploratory study, we show that some patients with ARVC have evidence for myocardial inflammation on FDG-PET, suggesting that myocarditis plays a role in disease pathogenesis.
Sections du résumé
BACKGROUND
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable heart muscle disease that causes sudden cardiac death in the young. Inflammatory myocardial infiltrates have been described at autopsy and on biopsy, but there are few data on the presence of myocarditis in living patients with ARVC using non-invasive imaging techniques. FDG-PET is a validated technique for detecting myocardial inflammation in clinically suspected myocarditis. We aimed to determine the prevalence of myocardial inflammation in patients with ARVC using
METHODS AND RESULTS
We performed a retrospective analysis of a single centre cohort of patients with ARVC referred for FDG-PET scans between 2012 and 2017 for investigation of symptoms or suspected device infection. Sixteen patients (12 male; age 42 ± 13 years) with a definite diagnosis of ARVC were identified. Seven had positive FDG-PET scans, two of whom had cardiac sarcoidosis on endomyocardial biopsy. Of the remaining five, two carried pathogenic desmoplakin mutations. FDG uptake was found in the left ventricular myocardium in all cases. One patient also had right ventricular uptake.
CONCLUSION
In this exploratory study, we show that some patients with ARVC have evidence for myocardial inflammation on FDG-PET, suggesting that myocarditis plays a role in disease pathogenesis.
Identifiants
pubmed: 30409737
pii: S0167-5273(18)34604-7
doi: 10.1016/j.ijcard.2018.10.083
pii:
doi:
Substances chimiques
Radiopharmaceuticals
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-104Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.