Plasma levels of soluble NCAM in multiple sclerosis.

Adult Aged Atrophy / diagnostic imaging Brain / diagnostic imaging Cross-Sectional Studies Disease Progression Female Humans Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis / blood Neural Cell Adhesion Molecules / blood Statistics, Nonparametric Vascular Cell Adhesion Molecule-1 / blood
Adhesion molecules ICAM-1 MRI Multiple sclerosis NCAM VCAM-1

Journal

Journal of the neurological sciences
ISSN: 1878-5883
Titre abrégé: J Neurol Sci
Pays: Netherlands
ID NLM: 0375403

Informations de publication

Date de publication:
15 01 2019
Historique:
received: 22 06 2018
revised: 24 09 2018
accepted: 26 10 2018
pubmed: 10 11 2018
medline: 23 7 2019
entrez: 10 11 2018
Statut: ppublish

Résumé

In multiple sclerosis (MS), several adhesion molecules are involved within the central nervous system in inflammatory and neurodegenerative processes that are associated to progressive disability and increasing brain atrophy. The neural cell adhesion molecule (NCAM) has been suggested to participate in the reparative mechanisms and in the remyelination processes, key issues in MS pathology. We aimed at investigating plasma levels of the seldom investigated soluble (s)NCAM, and as comparison those of intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1), and their association with clinical and MRI measures of lesion volumes and of global and regional atrophy. The cross-sectional study was conducted in 85 relapsing-remitting (RR)-MS, 53 progressive (P)-MS patients, and 42 healthy individuals (HI). Correlation of MRI measures with plasma levels of these adhesion molecules were not observed. In the MS and HI groups, sNCAM levels were significantly and positively associated with sVCAM-1 levels. Differently, the correlation between sICAM-1 and sVCAM-1 was observed only in MS patients. sNCAM and sVCAM-1 levels were higher in P-MS compared to HI (P = 0.05 and P = 0.028 respectively). The sVCAM-1 levels differed (P < 0.001) among DMTs groups and HI. The association of sNCAM plasma levels with MS disease, as well as differences in sVCAM-1 levels in patients receiving different DMTs, deserve further investigation.

Identifiants

DOI: 10.1016/j.jns.2018.10.023 PMID: 30412901
pubmed: 30412901
pii: S0022-510X(18)30433-7
doi: 10.1016/j.jns.2018.10.023
pii:
doi:

Substances chimiques

Neural Cell Adhesion Molecules 0
Vascular Cell Adhesion Molecule-1 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

36-41

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Nicole Ziliotto (N)

Department of Life Sciences and Biotechnology, University of Ferrara, Italy; Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Robert Zivadinov (R)

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Center for Biomedical Imaging, Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA.

Dejan Jakimovski (D)

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Marcello Baroni (M)

Department of Life Sciences and Biotechnology, University of Ferrara, Italy.

Veronica Tisato (V)

Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy.

Paola Secchiero (P)

Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy.

Niels Bergsland (N)

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Deepa P Ramasamy (DP)

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Bianca Weinstock-Guttman (B)

Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Francesco Bernardi (F)

Department of Life Sciences and Biotechnology, University of Ferrara, Italy.

Murali Ramanathan (M)

Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY, USA.

Giovanna Marchetti (G)

Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Italy. Electronic address: mrg@unife.it.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Plasma levels of soluble NCAM in multiple sclerosis.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Plasma levels of soluble NCAM in multiple sclerosis.
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Plasma levels of soluble NCAM in multiple sclerosis.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Plasma levels of soluble NCAM in multiple sclerosis.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Plasma levels of soluble NCAM in multiple sclerosis.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Plasma levels of soluble NCAM in multiple sclerosis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Plasma levels of soluble NCAM in multiple sclerosis.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Plasma levels of soluble NCAM in multiple sclerosis.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Plasma levels of soluble NCAM in multiple sclerosis.
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Plasma levels of soluble NCAM in multiple sclerosis.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Molécules d'adhérence cellulaire neuronale › Molécules d'adhérence cellulaire neurales › Plasma levels of soluble NCAM in multiple sclerosis.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Statistique non paramétrique › Plasma levels of soluble NCAM in multiple sclerosis.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Molécule-1 d'adhérence des cellules vasculaires › Plasma levels of soluble NCAM in multiple sclerosis.