An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation.

Animals Cell Differentiation Cell Movement / genetics Cell Proliferation / genetics Epidermal Cells / metabolism Epithelial-Mesenchymal Transition / genetics Gene Expression Regulation, Developmental Hair Follicle / growth & development Keratinocytes / metabolism Mice Skin / growth & development Stem Cells / cytology Transcription Factors / genetics Wound Healing / genetics Zinc Finger E-box-Binding Homeobox 1 / genetics
Ovol2 directional migration hair follicle skin stem cells wound healing

Journal

EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049

Informations de publication

Date de publication:
01 2019
Historique:
received: 14 04 2018
revised: 08 10 2018
accepted: 12 10 2018
pubmed: 11 11 2018
medline: 14 8 2019
entrez: 11 11 2018
Statut: ppublish

Résumé

Directional migration is inherently important for epithelial tissue regeneration and repair, but how it is precisely controlled and coordinated with cell proliferation is unclear. Here, we report that Ovol2, a transcriptional repressor that inhibits epithelial-to-mesenchymal transition (EMT), plays a crucial role in adult skin epithelial regeneration and repair.

Identifiants

DOI: 10.15252/embr.201846273 PMID: 30413481 PMC: PMC6322385
pubmed: 30413481
pii: embr.201846273
doi: 10.15252/embr.201846273
pmc: PMC6322385
pii:
doi:

Substances chimiques

MOVO protein, mouse 0
Transcription Factors 0
ZEB1 protein, mouse 0
Zinc Finger E-box-Binding Homeobox 1 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR067273
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR068074
Pays : United States
Organisme : NIAMS NIH HHS
ID : R56 AR064532
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR073159
Pays : United States

Informations de copyright

© 2018 The Authors.

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Auteurs

Daniel Haensel (D)

Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.

Peng Sun (P)

Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.

Adam L MacLean (AL)

Department of Mathematics, University of California, Irvine, CA, USA.

Xianghui Ma (X)

Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.

Yuan Zhou (Y)

Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.

Marc P Stemmler (MP)

Department of Experimental Medicine, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander University Erlangen-Nuernberg, Erlangen, Germany.

Simone Brabletz (S)

Department of Experimental Medicine, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander University Erlangen-Nuernberg, Erlangen, Germany.

Geert Berx (G)

Molecular and Cellular Oncology Lab, Department of Biomedical Molecular Biology, Ghent University, Zwijnaarde, Belgium.
Cancer Research Institute Ghent (CRIG), Ghent, Belgium.

Maksim V Plikus (MV)

Department of Developmental and Cell Biology, University of California, Irvine, CA, USA.

Qing Nie (Q)

Department of Mathematics, University of California, Irvine, CA, USA.
Department of Developmental and Cell Biology, University of California, Irvine, CA, USA.

Thomas Brabletz (T)

Department of Experimental Medicine, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander University Erlangen-Nuernberg, Erlangen, Germany.

Xing Dai (X)

Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA xdai@uci.edu.
ORCID: 0000-0001-8134-1365

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Cellules › Cellules épidermiques › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Transition épithélio-mésenchymateuse › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Système tégumentaire › Peau › Épiderme › Follicule pileux › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Cellules › Cellules épithéliales › Kératinocytes › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Système tégumentaire › Peau › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Cellules › Cellules souches › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cicatrisation de plaie › An Ovol2-Zeb1 transcriptional circuit...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Facteur de transcription Zeb1 › An Ovol2-Zeb1 transcriptional circuit...