Simone Brabletz

Affiliations

Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.

Publications (20)

Genome-wide cooperation of EMT transcription factor ZEB1 with YAP and AP-1 in breast cancer.

The EMBO journal

Avec: Nora Feldker , Fulvia Ferrazzi , Harald Schuhwerk , Sebastian A Widholz , Kerstin Guenther , Isabell Frisch , Kathrin Jakob , Julia Kleemann , Dania Riegel , Ulrike Bönisch , Sören Lukassen , Rebecca L Eccles , Christian Schmidl , Marc P Stemmler , Thomas Brabletz , Simone Brabletz

Epithelial-mesenchymal transition in the lacrimal gland morphogenesis, damage and repair.

The ocular surface

Avec: Swati Singh , Simone Brabletz , Philipp Arnold , Martin Schicht , Friedrich Paulsen

Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia.

The Journal of clinical investigation

Avec: Alhomidi Almotiri , Hamed Alzahrani , Juan Bautista Menendez-Gonzalez , Ali Abdelfattah , Badi Alotaibi , Lubaid Saleh , Adelle Greene , Mia Georgiou , Alex Gibbs , Amani Alsayari , Sarab Taha , Leigh-Anne Thomas , Dhruv Shah , Sarah Edkins , Peter Giles , Marc P Stemmler , Simone Brabletz , Thomas Brabletz , Ashleigh S Boyd , Florian A Siebzehnrubl , Neil P Rodrigues

Non-redundant functions of EMT transcription factors.

Nature cell biology

Avec: Marc P Stemmler , Rebecca L Eccles , Simone Brabletz , Thomas Brabletz

The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response.

Cell reports

Avec: Harald Schuhwerk , Julia Kleemann , Pooja Gupta , Ruthger van Roey , Isabell Armstark , Martina Kreileder , Nora Feldker , Vignesh Ramesh , Yussuf Hajjaj , Kathrin Fuchs , Mousumi Mahapatro , Mojca Hribersek , Marco Volante , Arwin Groenewoud , Felix B Engel , Paolo Ceppi , Markus Eckstein , Arndt Hartmann , Fabian Müller , Torsten Kroll , Marc P Stemmler , Simone Brabletz , Thomas Brabletz

Inactivation of

Disease models & mechanisms

Avec: Marina R Carpinelli , Michael E de Vries , Alana Auden , Tariq Butt , Zihao Deng , Darren D Partridge , Lee B Miles , Smitha R Georgy , Jody J Haigh , Charbel Darido , Simone Brabletz , Thomas Brabletz , Marc P Stemmler , Sebastian Dworkin , Stephen M Jane

An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation.

EMBO reports

Avec: Daniel Haensel , Peng Sun , Adam L MacLean , Xianghui Ma , Yuan Zhou , Marc P Stemmler , Simone Brabletz , Geert Berx , Maksim V Plikus , Qing Nie , Thomas Brabletz , Xing Dai

Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition.

Nature cell biology

Avec: Annemarie Schwab , Zhigang Rao , Jie Zhang , André Gollowitzer , Katharina Siebenkäs , Nino Bindel , Elisabetta D'Avanzo , Ruthger van Roey , Yussuf Hajjaj , Ece Özel , Isabell Armstark , Leonhard Bereuter , Fengting Su , Julia Grander , Ehsan Bonyadi Rad , Arwin Groenewoud , Felix B Engel , George W Bell , Whitney S Henry , José Pedro Friedmann Angeli , Marc P Stemmler , Simone Brabletz , Andreas Koeberle , Thomas Brabletz

Immunohistological Study of Palpebral Lobe of the Lacrimal Gland in Severe Dry Eyes Secondary to Stevens-Johnson Syndrome.

Current eye research

Avec: Swati Singh , Mohammad Javed Ali , Vikas Mittal , Simone Brabletz , Friedrich Paulsen

Dynamic EMT: a multi-tool for tumor progression.

The EMBO journal

Avec: Simone Brabletz , Harald Schuhwerk , Thomas Brabletz , Marc P Stemmler

Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells.

Cell death discovery

Avec: María Lasierra Losada , Melissa Pauler , Niels Vandamme , Steven Goossens , Geert Berx , Moritz Leppkes , Harald Schuhwerk , Simone Brabletz , Thomas Brabletz , Marc P Stemmler

A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling.

The EMBO journal

Avec: Lingxin Zhu , Yi Tang , Xiao-Yan Li , Samuel A Kerk , Costas A Lyssiotis , Wenqing Feng , Xiaoyue Sun , Geoffrey E Hespe , Zijun Wang , Marc P Stemmler , Simone Brabletz , Thomas Brabletz , Evan T Keller , Jun Ma , Jung-Sun Cho , Jingwen Yang , Stephen J Weiss

ZEB1 inhibits LHβ subunit transcription when over-expressed, but is dispensable for LH synthesis in mice.

Endocrinology

Avec: Hailey Schultz , Xiang Zhou , Carlos Agustín Isidro Alonso , Luisina Ongaro , Yeu-Farn Lin , Mary Loka , Thomas Brabletz , Simone Brabletz , Marc P Stemmler , Ulrich Boehm , Daniel J Bernard

The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma.

The Journal of pathology

Avec: Manuel Ruh , Marc P Stemmler , Isabell Frisch , Kathrin Fuchs , Ruthger van Roey , Julia Kleemann , Maike Roas , Harald Schuhwerk , Rebecca L Eccles , Abbas Agaimy , Daniel Baumhoer , Geert Berx , Fabian Müller , Thomas Brabletz , Simone Brabletz

The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus.

Cell reports

Avec: Bhavana Gupta , Adam C Errington , Ana Jimenez-Pascual , Vasileios Eftychidis , Simone Brabletz , Marc P Stemmler , Thomas Brabletz , David Petrik , Florian A Siebzehnrubl

Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity.

PLoS biology

Avec: Jueqiong Wang , Carlos Farkas , Aissa Benyoucef , Catherine Carmichael , Katharina Haigh , Nick Wong , Danny Huylebroeck , Marc P Stemmler , Simone Brabletz , Thomas Brabletz , Christian M Nefzger , Steven Goossens , Geert Berx , Jose M Polo , Jody J Haigh

Cytomegalovirus subverts macrophage identity.

Cell

Avec: Sebastian Baasch , Piero Giansanti , Julia Kolter , André Riedl , Aaron James Forde , Solveig Runge , Simon Zenke , Roland Elling , Anne Halenius , Simone Brabletz , Hartmut Hengel , Bernhard Kuster , Thomas Brabletz , Luka Cicin-Sain , Ramon Arens , Andreas Vlachos , Jan Christopher Rohr , Marc Philippe Stemmler , Manfred Kopf , Zsolt Ruzsics , Philipp Henneke

Zeb1 maintains long-term adult hematopoietic stem cell function and extramedullary hematopoiesis.

Experimental hematology

Avec: Alhomidi Almotiri , Ali Abdelfattah , Elis Storch , Marc P Stemmler , Simone Brabletz , Thomas Brabletz , Neil P Rodrigues

ZEB1-mediated fibroblast polarization controls inflammation and sensitivity to immunotherapy in colorectal cancer.

EMBO reports

Avec: Constantin Menche , Harald Schuhwerk , Isabell Armstark , Pooja Gupta , Kathrin Fuchs , Ruthger van Roey , Mohammed H Mosa , Anne Hartebrodt , Yussuf Hajjaj , Ana Clavel Ezquerra , Manoj K Selvaraju , Carol I Geppert , Stefanie Bärthel , Dieter Saur , Florian R Greten , Simone Brabletz , David B Blumenthal , Andreas Weigert , Thomas Brabletz , Henner F Farin , Marc P Stemmler

Ferroptosis in health and disease.

Redox biology

Avec: Carsten Berndt , Hamed Alborzinia , Vera Skafar Amen , Scott Ayton , Uladzimir Barayeu , Alexander Bartelt , Hülya Bayir , Christina M Bebber , Kivanc Birsoy , Jan P Böttcher , Simone Brabletz , Thomas Brabletz , Ashley R Brown , Bernhard Brüne , Giorgia Bulli , Alix Bruneau , Quan Chen , Gina M DeNicola , Tobias P Dick , Ayelén Distéfano , Scott J Dixon , Jan B Engler , Julia Esser-von Bieren , Maria Fedorova , José Pedro Friedmann Angeli , Manuel A Friese , Dominic C Fuhrmann , Ana J García-Sáez , Karolina Garbowicz , Magdalena Götz , Wei Gu , Linda Hammerich , Behrouz Hassannia , Xuejun Jiang , Aicha Jeridi , Yun Pyo Kang , Valerian E Kagan , David B Konrad , Stefan Kotschi , Peng Lei , Marlène Le Tertre , Sima Lev , Deguang Liang , Andreas Linkermann , Carolin Lohr , Svenja Lorenz , Tom Luedde , Axel Methner , Bernhard Michalke , Anna V Milton , Junxia Min , Eikan Mishima , Sebastian Müller , Hozumi Motohashi , Martina U Muckenthaler , Shohei Murakami , James A Olzmann , Gabriela Pagnussat , Zijan Pan , Thales Papagiannakopoulos , Lohans Pedrera Puentes , Derek A Pratt , Bettina Proneth , Lukas Ramsauer , Raphael Rodriguez , Yoshiro Saito , Felix Schmidt , Carina Schmitt , Almut Schulze , Annemarie Schwab , Anna Schwantes , Mariluz Soula , Benedikt Spitzlberger , Brent R Stockwell , Leonie Thewes , Oliver Thorn-Seshold , Shinya Toyokuni , Wulf Tonnus , Andreas Trumpp , Peter Vandenabeele , Tom Vanden Berghe , Vivek Venkataramani , Felix C E Vogel , Silvia von Karstedt , Fudi Wang , Frank Westermann , Chantal Wientjens , Christoph Wilhelm , Michele Wölk , Katherine Wu , Xin Yang , Fan Yu , Yilong Zou , Marcus Conrad

Réseau de co-auteurs

Thomas Brabletz 18 collaborations

Marc P Stemmler 16 collaborations

Harald Schuhwerk 6 collaborations

Ruthger van Roey 4 collaborations

Geert Berx 4 collaborations

Julia Kleemann 3 collaborations

Rebecca L Eccles 3 collaborations

Isabell Armstark 3 collaborations

Yussuf Hajjaj 3 collaborations

Kathrin Fuchs 3 collaborations

Nora Feldker 2 collaborations

Isabell Frisch 2 collaborations

Swati Singh 2 collaborations

Friedrich Paulsen 2 collaborations

Alhomidi Almotiri 2 collaborations

Ali Abdelfattah 2 collaborations

Florian A Siebzehnrubl 2 collaborations

Neil P Rodrigues 2 collaborations

Pooja Gupta 2 collaborations

Arwin Groenewoud 2 collaborations

Felix B Engel 2 collaborations

Fabian Müller 2 collaborations

Jody J Haigh 2 collaborations

Annemarie Schwab 2 collaborations

José Pedro Friedmann Angeli 2 collaborations

Steven Goossens 2 collaborations

Fulvia Ferrazzi 1 collaboration

Sebastian A Widholz 1 collaboration

Kerstin Guenther 1 collaboration

Kathrin Jakob 1 collaboration

Dania Riegel 1 collaboration

Ulrike Bönisch 1 collaboration

Sören Lukassen 1 collaboration

Christian Schmidl 1 collaboration

Philipp Arnold 1 collaboration

Martin Schicht 1 collaboration

Hamed Alzahrani 1 collaboration

Juan Bautista Menendez-Gonzalez 1 collaboration

Badi Alotaibi 1 collaboration

Lubaid Saleh 1 collaboration

Adelle Greene 1 collaboration

Mia Georgiou 1 collaboration

Alex Gibbs 1 collaboration

Amani Alsayari 1 collaboration

Sarab Taha 1 collaboration

Leigh-Anne Thomas 1 collaboration

Dhruv Shah 1 collaboration

Sarah Edkins 1 collaboration

Peter Giles 1 collaboration

Ashleigh S Boyd 1 collaboration

Martina Kreileder 1 collaboration

Vignesh Ramesh 1 collaboration

Mousumi Mahapatro 1 collaboration

Mojca Hribersek 1 collaboration

Marco Volante 1 collaboration

Paolo Ceppi 1 collaboration

Markus Eckstein 1 collaboration

Arndt Hartmann 1 collaboration

Torsten Kroll 1 collaboration

Marina R Carpinelli 1 collaboration

Michael E de Vries 1 collaboration

Alana Auden 1 collaboration

Tariq Butt 1 collaboration

Zihao Deng 1 collaboration

Darren D Partridge 1 collaboration

Lee B Miles 1 collaboration

Smitha R Georgy 1 collaboration

Charbel Darido 1 collaboration

Sebastian Dworkin 1 collaboration

Stephen M Jane 1 collaboration

Daniel Haensel 1 collaboration

Peng Sun 1 collaboration

Adam L MacLean 1 collaboration

Xianghui Ma 1 collaboration

Yuan Zhou 1 collaboration

Maksim V Plikus 1 collaboration

Qing Nie 1 collaboration

Xing Dai 1 collaboration

Zhigang Rao 1 collaboration

Jie Zhang 1 collaboration

André Gollowitzer 1 collaboration

Katharina Siebenkäs 1 collaboration

Nino Bindel 1 collaboration

Elisabetta D'Avanzo 1 collaboration

Ece Özel 1 collaboration

Leonhard Bereuter 1 collaboration

Fengting Su 1 collaboration

Julia Grander 1 collaboration

Ehsan Bonyadi Rad 1 collaboration

George W Bell 1 collaboration

Whitney S Henry 1 collaboration

Andreas Koeberle 1 collaboration

Mohammad Javed Ali 1 collaboration

Vikas Mittal 1 collaboration

María Lasierra Losada 1 collaboration

Melissa Pauler 1 collaboration

Niels Vandamme 1 collaboration

Moritz Leppkes 1 collaboration

Lingxin Zhu 1 collaboration

Yi Tang 1 collaboration

Xiao-Yan Li 1 collaboration

Samuel A Kerk 1 collaboration

Costas A Lyssiotis 1 collaboration

Wenqing Feng 1 collaboration

Xiaoyue Sun 1 collaboration

Geoffrey E Hespe 1 collaboration

Zijun Wang 1 collaboration

Evan T Keller 1 collaboration

Jun Ma 1 collaboration

Jung-Sun Cho 1 collaboration

Jingwen Yang 1 collaboration

Stephen J Weiss 1 collaboration

Hailey Schultz 1 collaboration

Xiang Zhou 1 collaboration

Carlos Agustín Isidro Alonso 1 collaboration

Luisina Ongaro 1 collaboration

Yeu-Farn Lin 1 collaboration

Mary Loka 1 collaboration

Ulrich Boehm 1 collaboration

Daniel J Bernard 1 collaboration

Manuel Ruh 1 collaboration

Maike Roas 1 collaboration

Abbas Agaimy 1 collaboration

Daniel Baumhoer 1 collaboration

Bhavana Gupta 1 collaboration

Adam C Errington 1 collaboration

Ana Jimenez-Pascual 1 collaboration

Vasileios Eftychidis 1 collaboration

David Petrik 1 collaboration

Jueqiong Wang 1 collaboration

Carlos Farkas 1 collaboration

Aissa Benyoucef 1 collaboration

Catherine Carmichael 1 collaboration

Katharina Haigh 1 collaboration

Nick Wong 1 collaboration

Danny Huylebroeck 1 collaboration

Christian M Nefzger 1 collaboration

Jose M Polo 1 collaboration

Sebastian Baasch 1 collaboration

Piero Giansanti 1 collaboration

Julia Kolter 1 collaboration

André Riedl 1 collaboration

Aaron James Forde 1 collaboration

Solveig Runge 1 collaboration

Simon Zenke 1 collaboration

Roland Elling 1 collaboration

Anne Halenius 1 collaboration

Hartmut Hengel 1 collaboration

Bernhard Kuster 1 collaboration

Luka Cicin-Sain 1 collaboration

Ramon Arens 1 collaboration

Andreas Vlachos 1 collaboration

Jan Christopher Rohr 1 collaboration

Marc Philippe Stemmler 1 collaboration

Manfred Kopf 1 collaboration

Zsolt Ruzsics 1 collaboration

Philipp Henneke 1 collaboration

Elis Storch 1 collaboration

Constantin Menche 1 collaboration

Mohammed H Mosa 1 collaboration

Anne Hartebrodt 1 collaboration

Ana Clavel Ezquerra 1 collaboration

Manoj K Selvaraju 1 collaboration

Carol I Geppert 1 collaboration

Stefanie Bärthel 1 collaboration

Dieter Saur 1 collaboration

Florian R Greten 1 collaboration

David B Blumenthal 1 collaboration

Andreas Weigert 1 collaboration

Henner F Farin 1 collaboration

Carsten Berndt 1 collaboration

Hamed Alborzinia 1 collaboration

Vera Skafar Amen 1 collaboration

Scott Ayton 1 collaboration

Uladzimir Barayeu 1 collaboration

Alexander Bartelt 1 collaboration

Hülya Bayir 1 collaboration

Christina M Bebber 1 collaboration

Kivanc Birsoy 1 collaboration

Jan P Böttcher 1 collaboration

Ashley R Brown 1 collaboration

Bernhard Brüne 1 collaboration

Giorgia Bulli 1 collaboration

Alix Bruneau 1 collaboration

Quan Chen 1 collaboration

Gina M DeNicola 1 collaboration

Tobias P Dick 1 collaboration

Ayelén Distéfano 1 collaboration

Scott J Dixon 1 collaboration

Jan B Engler 1 collaboration

Julia Esser-von Bieren 1 collaboration

Maria Fedorova 1 collaboration

Manuel A Friese 1 collaboration

Dominic C Fuhrmann 1 collaboration

Ana J García-Sáez 1 collaboration

Karolina Garbowicz 1 collaboration

Magdalena Götz 1 collaboration

Wei Gu 1 collaboration

Linda Hammerich 1 collaboration

Behrouz Hassannia 1 collaboration

Xuejun Jiang 1 collaboration

Aicha Jeridi 1 collaboration

Yun Pyo Kang 1 collaboration

Valerian E Kagan 1 collaboration

David B Konrad 1 collaboration

Stefan Kotschi 1 collaboration

Peng Lei 1 collaboration

Marlène Le Tertre 1 collaboration

Sima Lev 1 collaboration

Deguang Liang 1 collaboration

Andreas Linkermann 1 collaboration

Carolin Lohr 1 collaboration

Svenja Lorenz 1 collaboration

Tom Luedde 1 collaboration

Axel Methner 1 collaboration

Bernhard Michalke 1 collaboration

Anna V Milton 1 collaboration

Junxia Min 1 collaboration

Eikan Mishima 1 collaboration

Sebastian Müller 1 collaboration

Hozumi Motohashi 1 collaboration

Martina U Muckenthaler 1 collaboration

Shohei Murakami 1 collaboration

James A Olzmann 1 collaboration

Gabriela Pagnussat 1 collaboration

Zijan Pan 1 collaboration

Thales Papagiannakopoulos 1 collaboration

Lohans Pedrera Puentes 1 collaboration

Derek A Pratt 1 collaboration

Bettina Proneth 1 collaboration

Lukas Ramsauer 1 collaboration

Raphael Rodriguez 1 collaboration

Yoshiro Saito 1 collaboration

Felix Schmidt 1 collaboration

Carina Schmitt 1 collaboration

Almut Schulze 1 collaboration

Anna Schwantes 1 collaboration

Mariluz Soula 1 collaboration

Benedikt Spitzlberger 1 collaboration

Brent R Stockwell 1 collaboration

Leonie Thewes 1 collaboration

Oliver Thorn-Seshold 1 collaboration

Shinya Toyokuni 1 collaboration

Wulf Tonnus 1 collaboration

Andreas Trumpp 1 collaboration

Peter Vandenabeele 1 collaboration

Tom Vanden Berghe 1 collaboration

Vivek Venkataramani 1 collaboration

Felix C E Vogel 1 collaboration

Silvia von Karstedt 1 collaboration

Fudi Wang 1 collaboration

Frank Westermann 1 collaboration

Chantal Wientjens 1 collaboration

Christoph Wilhelm 1 collaboration

Michele Wölk 1 collaboration

Katherine Wu 1 collaboration

Xin Yang 1 collaboration

Fan Yu 1 collaboration

Yilong Zou 1 collaboration

Marcus Conrad 1 collaboration