Non-redundant functions of EMT transcription factors.
Journal
Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
14
05
2018
accepted:
16
08
2018
entrez:
4
1
2019
pubmed:
4
1
2019
medline:
16
4
2019
Statut:
ppublish
Résumé
Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to be debated. In this Review, we identify and describe specific, non-redundant functions of the different EMT-TFs and discuss the reasons that may underlie disputes about EMT in cancer.
Identifiants
pubmed: 30602760
doi: 10.1038/s41556-018-0196-y
pii: 10.1038/s41556-018-0196-y
doi:
Substances chimiques
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102-112Références
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