A novel T-cell epitope in the transmembrane region of the hepatitis B virus envelope protein responds upon dendritic cell expansion.
Adult
CD8-Positive T-Lymphocytes
/ cytology
Cell Differentiation
Cell Proliferation
Cells, Cultured
Dendritic Cells
/ chemistry
Epitope Mapping
Epitopes, T-Lymphocyte
/ chemistry
Female
Hepatitis B
/ genetics
Hepatitis B Surface Antigens
/ chemistry
Hepatitis B virus
/ chemistry
Humans
Immunodominant Epitopes
/ chemistry
Interferon-gamma
/ genetics
Male
Middle Aged
Monocytes
/ cytology
Young Adult
Journal
Archives of virology
ISSN: 1432-8798
Titre abrégé: Arch Virol
Pays: Austria
ID NLM: 7506870
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
17
04
2018
accepted:
21
10
2018
pubmed:
12
11
2018
medline:
21
3
2019
entrez:
12
11
2018
Statut:
ppublish
Résumé
Restoring antiviral immunity is a promising immunotherapeutic approach to the treatment of chronic hepatitis B virus (HBV) infection. Dendritic cells play a crucial role in triggering antiviral immunity. In this study, we identified immunodominant epitopes prevalent in CD8
Identifiants
pubmed: 30415392
doi: 10.1007/s00705-018-4095-0
pii: 10.1007/s00705-018-4095-0
pmc: PMC6373280
doi:
Substances chimiques
Epitopes, T-Lymphocyte
0
Hepatitis B Surface Antigens
0
Immunodominant Epitopes
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
483-495Subventions
Organisme : International Cooperation Project of Guangzhou Science and Technology Program
ID : 2016201604030021
Organisme : National Grant Program on Key Infectious Disease
ID : 2014ZX10002002-002
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