Early intraventricular baclofen therapy (IVB) for children with dystonic and dysautonomic storm.
Adolescent
Autonomic Nervous System Diseases
/ complications
Baclofen
/ administration & dosage
Child
Dystonia
/ complications
Female
Humans
Hypoxia, Brain
/ complications
Infusion Pumps, Implantable
Injections, Intraventricular
Male
Muscle Relaxants, Central
/ administration & dosage
Secondary Prevention
Treatment Outcome
Baclofen
Dystonia
Intraventricular baclofen therapy
Journal
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
ISSN: 1433-0350
Titre abrégé: Childs Nerv Syst
Pays: Germany
ID NLM: 8503227
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
25
09
2018
accepted:
04
11
2018
pubmed:
13
11
2018
medline:
25
2
2020
entrez:
13
11
2018
Statut:
ppublish
Résumé
Intrathecal baclofen (ITB) is an effective treatment for managing primary and secondary dystonia. Intraventricular baclofen (IVB) was first developed to allow treating patients in which the use of ITB was difficult due to anatomic anomalies. After that, several studies indicate that intraventricular administration of baclofen, is more effective than ITB in refractory dystonia. We report three cases of children with acute dystonic and dysautonomic storm, treated with IVB. The clinical outcome was satisfactory. The response to the treatment continued after the pump disconnection, suggesting that in this kind of cerebral dysregulations, short-term IVB is an effective treatment. Early treatment with IVB may be an effective option in patients with post-anoxic dysautonomic and dystonic storm.
Identifiants
pubmed: 30417210
doi: 10.1007/s00381-018-4002-8
pii: 10.1007/s00381-018-4002-8
doi:
Substances chimiques
Muscle Relaxants, Central
0
Baclofen
H789N3FKE8
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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