Impact of early diagnosis on clinical characteristics of an Italian sample of people with multiple sclerosis recruited online.
Disease modifying treatment
Early diagnosis
Multiple sclerosis
Web-based survey
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
30
04
2018
revised:
19
10
2018
accepted:
28
10
2018
pubmed:
13
11
2018
medline:
17
4
2019
entrez:
13
11
2018
Statut:
ppublish
Résumé
In order to anticipate the diagnosis of Multiple Sclerosis (MS), the diagnostic criteria had been reviewed several times in the last years. We wanted to understand whether earlier diagnoses of MS have impacted on therapeutic management of the disease. We designed a 22-item survey posted on SMsocialnetwork, a webplatform with a medical supervision, dedicated to Italian MS patients. We collected socio-demographic data, disease and treatment-related information of 1000 patients. The median age at diagnosis significantly decreased over years. In the last decades the time delay between disease onset and diagnosis reduced, the disease phenotypes at diagnosis shifted from progressive form to relapsing ones and clinically isolated syndrome, the number of early treated patients increased over time. We showed, verifying a large sample of patients in a reallife setting, that the improvement of the diagnostic process allowed the anticipation of MS diagnosis over years and had a huge impact in terms of treatment approach.
Sections du résumé
BACKGROUND
BACKGROUND
In order to anticipate the diagnosis of Multiple Sclerosis (MS), the diagnostic criteria had been reviewed several times in the last years.
OBJECTIVE
OBJECTIVE
We wanted to understand whether earlier diagnoses of MS have impacted on therapeutic management of the disease.
METHODS
METHODS
We designed a 22-item survey posted on SMsocialnetwork, a webplatform with a medical supervision, dedicated to Italian MS patients. We collected socio-demographic data, disease and treatment-related information of 1000 patients.
RESULTS
RESULTS
The median age at diagnosis significantly decreased over years. In the last decades the time delay between disease onset and diagnosis reduced, the disease phenotypes at diagnosis shifted from progressive form to relapsing ones and clinically isolated syndrome, the number of early treated patients increased over time.
CONCLUSION
CONCLUSIONS
We showed, verifying a large sample of patients in a reallife setting, that the improvement of the diagnostic process allowed the anticipation of MS diagnosis over years and had a huge impact in terms of treatment approach.
Identifiants
pubmed: 30419509
pii: S2211-0348(18)30480-2
doi: 10.1016/j.msard.2018.10.113
pii:
doi:
Substances chimiques
Immunologic Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
239-246Informations de copyright
Copyright © 2018 The Author(s). Published by Elsevier B.V. All rights reserved.