Detection of an animal-derived G4P[6] group A rotavirus strain in a symptomatic child, in Italy.
Diarrhea
G4P[6]
Human
Italy
Rotavirus
Swine
Journal
Virus research
ISSN: 1872-7492
Titre abrégé: Virus Res
Pays: Netherlands
ID NLM: 8410979
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
12
09
2018
revised:
05
11
2018
accepted:
06
11
2018
pubmed:
14
11
2018
medline:
23
1
2019
entrez:
14
11
2018
Statut:
ppublish
Résumé
During 2017, a G4P[6] group A rotavirus strain was identified in the feces of an Italian child hospitalized for acute gastroenteritis in Southern Italy. Nucleotide sequencing of the 11 genomic segments, revealed the G4-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1 genotype constellation. Phylogenetic analyses of the gene segments investigated revealed high nucleotide sequence identities with G4P[6] RVA strains detected previously in pigs and in humans. The human strains related to the Italian G4P[6] were mainly reported from Asia, and were detected after an inter-species transmission event from swine. This study reports the genotyping and phylogenetic analysis of a G4P[6] RVA strain presenting a genomic constellation never detected before in Italy. In addition, this strain was able to cause AGE symptoms in a healthy child, successively hospitalized. The molecular characterization suggested zoonotic origin and inter-species transmission of this strain from swine, living open the possibility of its importation from abroad.
Identifiants
pubmed: 30423360
pii: S0168-1702(18)30566-5
doi: 10.1016/j.virusres.2018.11.003
pii:
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7-11Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.