Synthesis, characterization, crystal structure of novel bis-thiomethylcyclohexanone derivatives and their inhibitory properties against some metabolic enzymes.
Acetazolamide
/ chemistry
Acetylcholinesterase
/ chemistry
Butyrylcholinesterase
/ chemistry
Carbonic Anhydrase I
/ antagonists & inhibitors
Carbonic Anhydrase II
/ antagonists & inhibitors
Carbonic Anhydrase Inhibitors
/ chemical synthesis
Cholinesterase Inhibitors
/ chemical synthesis
Crystallography, X-Ray
Cyclohexanones
/ chemical synthesis
Humans
Kinetics
Molecular Structure
Sulfides
/ chemical synthesis
Tacrine
/ chemistry
Acetylcholinesterase
Bis-thiomethylcyclohexanone
Carbonic anhydrase
Crystal structure
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
06
09
2018
revised:
03
10
2018
accepted:
01
11
2018
pubmed:
15
11
2018
medline:
31
8
2019
entrez:
15
11
2018
Statut:
ppublish
Résumé
In this study, a series of novel bis-thiomethylcyclohexanone compounds (3a-3j) were synthesized by the addition of thio-Michael to the bis-chalcones under mild reaction conditions. The bis-thiomethylcyclohexanone derivatives (bis-sulfides) were characterized by
Identifiants
pubmed: 30428418
pii: S0045-2068(18)30994-5
doi: 10.1016/j.bioorg.2018.11.001
pii:
doi:
Substances chimiques
Carbonic Anhydrase Inhibitors
0
Cholinesterase Inhibitors
0
Cyclohexanones
0
Sulfides
0
Tacrine
4VX7YNB537
Acetylcholinesterase
EC 3.1.1.7
Butyrylcholinesterase
EC 3.1.1.8
Carbonic Anhydrase I
EC 4.2.1.-
Carbonic Anhydrase II
EC 4.2.1.-
Acetazolamide
O3FX965V0I
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
393-404Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.