Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination.
Animals
Autoantibodies
/ blood
Behavior, Animal
Corpus Callosum
/ drug effects
Cuprizone
Cyclopentanes
/ therapeutic use
Cytokines
/ metabolism
Demyelinating Diseases
/ drug therapy
Disease Models, Animal
Furans
/ therapeutic use
Ginkgolides
/ therapeutic use
Humans
Immunity, Humoral
/ drug effects
Inflammation
/ drug therapy
Inflammation Mediators
/ metabolism
Male
Mice
Mice, Inbred C57BL
Multiple Sclerosis
/ drug therapy
Myelin-Oligodendrocyte Glycoprotein
/ immunology
Neuroprotective Agents
/ therapeutic use
Oligodendroglia
/ drug effects
Bilobalide
Cuprizone-induced demyelination
Immunomodulation
Remyelination
Journal
International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
14
06
2018
revised:
25
09
2018
accepted:
25
09
2018
pubmed:
18
11
2018
medline:
15
5
2019
entrez:
17
11
2018
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system characterized by recurrent and progressive demyelination, neuroinflammation and oligodendrocyte loss. The cuprizone (CPZ) model is characterized by primary and reversible demyelination, accompanied by oligodendrocyte loss and neuroinflammation. In the current study, we explored the efficiency of Bilobalide in the demyelination and remyelination. The results demonstrate that Bilobalide improved behavioral abnormality and promoted remyelination in the corpus callosum by using Luxol Fast Blue, Black Gold II and myelin basic protein (MBP) staining. We for the first time found that CPZ caused the splenic atrophy and induced the formation of myelin oligodendrocyte glycoprotein (MOG) antibody, which was attenuated by Bilobalide. Thus, Bilobalide decreased the loss of O4+ oligodendrocytes possibly through MOG antibody-dependent cell cytotoxicity. Bilobalide also prevented the infiltration of CD4
Identifiants
pubmed: 30445309
pii: S1567-5769(18)30747-1
doi: 10.1016/j.intimp.2018.09.041
pii:
doi:
Substances chimiques
Autoantibodies
0
Cyclopentanes
0
Cytokines
0
Furans
0
Ginkgolides
0
Inflammation Mediators
0
Myelin-Oligodendrocyte Glycoprotein
0
Neuroprotective Agents
0
Cuprizone
5N16U7E0AO
bilobalide
M81D2O8H7U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
69-81Informations de copyright
Copyright © 2018. Published by Elsevier B.V.