Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors.
Animals
Behavior, Addictive
/ genetics
Conditioning, Classical
/ drug effects
Conditioning, Operant
/ drug effects
Dentate Gyrus
/ drug effects
Doublecortin Domain Proteins
Doublecortin Protein
Hippocampus
/ drug effects
Male
Memory
/ drug effects
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microglia
/ drug effects
Microtubule-Associated Proteins
/ metabolism
Morphine
/ pharmacology
Myeloid Differentiation Factor 88
/ deficiency
Narcotics
/ pharmacology
Neural Stem Cells
/ drug effects
Neurogenesis
/ drug effects
Neurons
/ drug effects
Neuropeptides
/ metabolism
Opioid-Related Disorders
/ genetics
Reward
Extinction
Microglia
Morphine
MyD88
Neurogenesis
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
24
07
2018
revised:
09
11
2018
accepted:
13
11
2018
pubmed:
18
11
2018
medline:
29
2
2020
entrez:
18
11
2018
Statut:
ppublish
Résumé
Drugs of abuse promote a potent immune response in central nervous system (CNS) via the activation of microglia and astrocytes. However, the molecular mechanisms underlying microglial activation during addiction are not well known. We developed and functionally characterized a novel transgenic mouse (Cx3cr1-CreBT
Identifiants
pubmed: 30447281
pii: S0889-1591(18)30363-5
doi: 10.1016/j.bbi.2018.11.010
pmc: PMC6348129
mid: NIHMS1514411
pii:
doi:
Substances chimiques
Dcx protein, mouse
0
Doublecortin Domain Proteins
0
Doublecortin Protein
0
Microtubule-Associated Proteins
0
Myd88 protein, mouse
0
Myeloid Differentiation Factor 88
0
Narcotics
0
Neuropeptides
0
Morphine
76I7G6D29C
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
104-115Subventions
Organisme : NIDA NIH HHS
ID : R01 DA034185
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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