Enhanced inter-compartmental Ca
Apoptosis
Biomarkers
Calcium
/ metabolism
Calcium Signaling
/ drug effects
Cell Line
Cell Proliferation
Cell Respiration
Cell Survival
Cellular Senescence
Endoplasmic Reticulum
/ metabolism
Endothelial Cells
/ metabolism
Energy Metabolism
Homeostasis
Intracellular Space
/ metabolism
Mitochondria
/ drug effects
Reactive Oxygen Species
/ metabolism
Resveratrol
/ pharmacology
Signal Transduction
Calcium signaling
ER-mitochondrial coupling
Endoplasmic reticulum
Mitochondria
Vascular aging
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
11
10
2018
revised:
02
11
2018
accepted:
06
11
2018
pubmed:
21
11
2018
medline:
22
3
2019
entrez:
21
11
2018
Statut:
ppublish
Résumé
Senescence is characterized by a gradual decline in cellular functions, including changes in energy homeostasis and decreased proliferation activity. As cellular power plants, contributors to signal transduction, sources of reactive oxygen species (ROS) and executors of programmed cell death, mitochondria are in a unique position to affect aging-associated processes of cellular decline. Notably, metabolic activation of mitochondria is tightly linked to Ca In this study, we investigated age-related changes in mitochondrial Ca We describe that in aged endothelial cells, increased ER-mitochondrial Ca By unveiling aging-related changes in the inter-organelle tethering and Ca
Sections du résumé
BACKGROUND
Senescence is characterized by a gradual decline in cellular functions, including changes in energy homeostasis and decreased proliferation activity. As cellular power plants, contributors to signal transduction, sources of reactive oxygen species (ROS) and executors of programmed cell death, mitochondria are in a unique position to affect aging-associated processes of cellular decline. Notably, metabolic activation of mitochondria is tightly linked to Ca
METHODS
In this study, we investigated age-related changes in mitochondrial Ca
RESULTS
We describe that in aged endothelial cells, increased ER-mitochondrial Ca
CONCLUSION
By unveiling aging-related changes in the inter-organelle tethering and Ca
Identifiants
pubmed: 30458321
pii: S2213-2317(18)30947-9
doi: 10.1016/j.redox.2018.11.003
pmc: PMC6243020
pii:
doi:
Substances chimiques
Biomarkers
0
Reactive Oxygen Species
0
Resveratrol
Q369O8926L
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
458-466Subventions
Organisme : Austrian Science Fund FWF
ID : J 4205
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 28529
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : W 1226
Pays : Austria
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
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