Evaluation of the Associations Between Cervical Microbiota and HPV Infection, Clearance, and Persistence in Cytologically Normal Women.
Adult
Aged
Bacteria
/ classification
Cervix Uteri
/ cytology
China
/ epidemiology
Cytodiagnosis
Female
Follow-Up Studies
Genotype
High-Throughput Nucleotide Sequencing
Humans
Incidence
Middle Aged
Papillomaviridae
/ isolation & purification
Papillomavirus Infections
/ complications
Prognosis
Uterine Cervical Neoplasms
/ epidemiology
Journal
Cancer prevention research (Philadelphia, Pa.)
ISSN: 1940-6215
Titre abrégé: Cancer Prev Res (Phila)
Pays: United States
ID NLM: 101479409
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
01
07
2018
revised:
07
09
2018
accepted:
05
11
2018
pubmed:
23
11
2018
medline:
7
3
2020
entrez:
23
11
2018
Statut:
ppublish
Résumé
The aim of this study was to investigate the associations between cervical microbiota and different human papillomavirus (HPV) infection statuses in cytologically normal women. The cervical microbiota of HPV-positive or -negative women with a normal cytologic diagnosis was characterized and compared using 16S rDNA-based high-throughput sequencing, and the differences in cervical microbiota associated with new acquisition, persistence, and clearances of HPV genotypes were analyzed via one-year follow-up. The results showed that the cervical microbial richness of HPV-positive women was lower than for HPV-negative women, and the difference was more significant in the postmenopausal group relative to the premenopausal group.
Identifiants
pubmed: 30463989
pii: 1940-6207.CAPR-18-0233
doi: 10.1158/1940-6207.CAPR-18-0233
doi:
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-56Informations de copyright
©2018 American Association for Cancer Research.