Trypsin-encoding
Adolescent
Alleles
Antineoplastic Agents
/ administration & dosage
Asparaginase
/ administration & dosage
Child
Child, Preschool
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans
Infant
Male
Models, Biological
Pancreatitis
/ etiology
Phenotype
Polyethylene Glycols
/ administration & dosage
Polymorphism, Single Nucleotide
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ complications
Trypsin
/ genetics
Trypsinogen
/ genetics
Journal
Haematologica
ISSN: 1592-8721
Titre abrégé: Haematologica
Pays: Italy
ID NLM: 0417435
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
06
06
2018
accepted:
16
11
2018
pubmed:
24
11
2018
medline:
12
5
2020
entrez:
24
11
2018
Statut:
ppublish
Résumé
Asparaginase-associated pancreatitis is a life-threatening toxicity to childhood acute lymphoblastic leukemia treatment. To elucidate genetic predisposition and asparaginase-associated pancreatitis pathogenesis, ten trial groups contributed remission samples from patients aged 1.0-17.9 years treated for acute lymphoblastic leukemia between 2000 and 2016. Cases (n=244) were defined by the presence of at least two of the following criteria: (i) abdominal pain; (ii) levels of pancreatic enzymes ≥3 × upper normal limit; and (iii) imaging compatible with pancreatitis. Controls (n=1320) completed intended asparaginase therapy, with 78% receiving ≥8 injections of pegylated-asparaginase, without developing asparaginase-associated pancreatitis. rs62228256 on 20q13.2 showed the strongest association with the development of asparaginase-associated pancreatitis (odds ratio=3.75;
Identifiants
pubmed: 30467200
pii: haematol.2018.199356
doi: 10.3324/haematol.2018.199356
pmc: PMC6395330
doi:
Substances chimiques
Antineoplastic Agents
0
PRSS2 protein, human
103964-84-7
Polyethylene Glycols
3WJQ0SDW1A
pegaspargase
7D96IR0PPM
Trypsinogen
9002-08-8
PRSS1 protein, human
EC 3.4.21.4
Trypsin
EC 3.4.21.4
Asparaginase
EC 3.5.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
556-563Subventions
Organisme : Blood Cancer UK
ID : 10060
Pays : United Kingdom
Organisme : Blood Cancer UK
ID : 15014
Pays : United Kingdom
Organisme : Blood Cancer UK
ID : 12026
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : R00 ES023504
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES025052
Pays : United States
Informations de copyright
Copyright© 2019 Ferrata Storti Foundation.
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