Neurochemical correlates of functional decline in amyotrophic lateral sclerosis.
Adult
Aged
Amyotrophic Lateral Sclerosis
/ diagnosis
Aspartic Acid
/ analogs & derivatives
Case-Control Studies
Disease Progression
Female
Glutamic Acid
/ metabolism
Humans
Longitudinal Studies
Male
Middle Aged
Motor Cortex
/ metabolism
Motor Neurons
/ metabolism
Pons
/ metabolism
Prognosis
Proton Magnetic Resonance Spectroscopy
Upper Extremity
7 tesla
amyotrophic lateral sclerosis
biomarker
longitudinal
motor cortex
proton MRS
Journal
Journal of neurology, neurosurgery, and psychiatry
ISSN: 1468-330X
Titre abrégé: J Neurol Neurosurg Psychiatry
Pays: England
ID NLM: 2985191R
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
10
05
2018
revised:
08
08
2018
accepted:
19
09
2018
pubmed:
24
11
2018
medline:
18
12
2019
entrez:
24
11
2018
Statut:
ppublish
Résumé
To determine whether proton magnetic resonance spectroscopy ( Nineteen participants with early-stage ALS and 18 age-matched and sex ratio-matched controls underwent ultra-high field Motor cortex total Neurochemical changes in motor areas of the brain are associated with functional decline in corresponding body regions.
Identifiants
pubmed: 30467209
pii: jnnp-2018-318795
doi: 10.1136/jnnp-2018-318795
pmc: PMC6467050
mid: NIHMS1022005
doi:
Substances chimiques
Aspartic Acid
30KYC7MIAI
Glutamic Acid
3KX376GY7L
N-acetylaspartate
997-55-7
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
294-301Subventions
Organisme : NINDS NIH HHS
ID : P30 NS076408
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015894
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS080816
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000114
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: IC, DKD, LEE, MM, GM and GG report no disclosures. DW consults for Acceleron Pharma and receives research support from the ALS Association, Acceleron Pharma, Pharnext and FLEX Pharma. GO received research support from Takeda Pharmaceuticals and NeuroVia.
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