Social-emotional processing in nonverbal individuals with Angelman syndrome: evidence from brain responses to known and novel names.
Adaptation, Psychological
/ physiology
Adolescent
Adult
Affect
/ physiology
Angelman Syndrome
/ complications
Cerebral Cortex
/ physiopathology
Child
Child, Preschool
Electroencephalography
Evoked Potentials, Auditory
/ physiology
Female
Humans
Language Development Disorders
/ etiology
Male
Middle Aged
Names
Nonverbal Communication
/ physiology
Recognition, Psychology
/ physiology
Social Perception
Social Skills
Speech Perception
/ physiology
Young Adult
Angelman syndrome
auditory
event-related potential
name
nonverbal
social
Journal
Journal of intellectual disability research : JIDR
ISSN: 1365-2788
Titre abrégé: J Intellect Disabil Res
Pays: England
ID NLM: 9206090
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
03
10
2018
revised:
29
10
2018
accepted:
30
10
2018
pubmed:
24
11
2018
medline:
22
7
2020
entrez:
24
11
2018
Statut:
ppublish
Résumé
The combination of intellectual, communicative and motor deficits limits the use of standardised behavioural assessments in individuals with Angelman syndrome (AS). The current study aimed to objectively evaluate the extent of social-emotional processing in AS using auditory event-related potentials (ERPs) during passive exposure to spoken stimuli. Auditory ERP responses were recorded in 13 nonverbal individuals with the deletion subtype of AS, age 4-45 years, during the name recognition paradigm, in which their own names and names of close others (relative or friend) were presented among novel names. No behavioural responses were required. Contrary to findings in typical children and adults, there was no significant evidence of differential neural response to known vs. novel names in participants with AS. Nevertheless, greater amplitude differences between known and unknown names demonstrated the predicted association with better interpersonal relationships and receptive communication abilities. These findings indicate good tolerability of ERP procedures (85% success rate). The lack of own name differentiation is consistent with increased incidence of the autism-related symptoms in AS. Strong associations between the caregiver reports of adaptive functioning and neural indices of known name recognition support the utility of brain-based measures for objectively evaluating cognitive and affective processes in nonverbal persons with neurodevelopmental disorders.
Sections du résumé
BACKGROUND
The combination of intellectual, communicative and motor deficits limits the use of standardised behavioural assessments in individuals with Angelman syndrome (AS). The current study aimed to objectively evaluate the extent of social-emotional processing in AS using auditory event-related potentials (ERPs) during passive exposure to spoken stimuli.
METHODS
Auditory ERP responses were recorded in 13 nonverbal individuals with the deletion subtype of AS, age 4-45 years, during the name recognition paradigm, in which their own names and names of close others (relative or friend) were presented among novel names. No behavioural responses were required.
RESULTS
Contrary to findings in typical children and adults, there was no significant evidence of differential neural response to known vs. novel names in participants with AS. Nevertheless, greater amplitude differences between known and unknown names demonstrated the predicted association with better interpersonal relationships and receptive communication abilities.
CONCLUSIONS
These findings indicate good tolerability of ERP procedures (85% success rate). The lack of own name differentiation is consistent with increased incidence of the autism-related symptoms in AS. Strong associations between the caregiver reports of adaptive functioning and neural indices of known name recognition support the utility of brain-based measures for objectively evaluating cognitive and affective processes in nonverbal persons with neurodevelopmental disorders.
Identifiants
pubmed: 30468263
doi: 10.1111/jir.12570
pmc: PMC6924168
mid: NIHMS1062704
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
244-254Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD083211
Pays : United States
Informations de copyright
© 2018 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.
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