Shifts in the functional topography of frontal cortex-striatum connectivity in alcohol use disorder.
Adult
Aged
Alcoholism
/ diagnostic imaging
Case-Control Studies
Caudate Nucleus
/ diagnostic imaging
Female
Frontal Lobe
/ diagnostic imaging
Functional Neuroimaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neostriatum
/ diagnostic imaging
Neural Pathways
Nucleus Accumbens
/ diagnostic imaging
Prefrontal Cortex
/ diagnostic imaging
Principal Component Analysis
Putamen
/ diagnostic imaging
Ventral Striatum
/ diagnostic imaging
Young Adult
alcohol addiction
cognitive control
functional magnetic resonance imaging
resting state
top down
ventral striatum
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
25
06
2018
revised:
09
10
2018
accepted:
09
10
2018
pubmed:
24
11
2018
medline:
29
10
2020
entrez:
24
11
2018
Statut:
ppublish
Résumé
Frontostriatal circuits are centrally involved in the selection of behavioral programs and play a prominent role in alcohol use disorder (AUD) as well as other mental disorders. However, how frontal regions change their striatal connectivity to implement adaptive cognitive control is still not fully understood. Here, we developed an approach for functional magnetic resonance imaging (fMRI) connectivity analysis in which we change the focus from connectivity to individual voxels towards spatial information about the location of strongest functional connectivity. In resting state data of n = 66 participants with AUD and n = 40 healthy controls (HC) we used the approach to estimate frontostriatal connectivity gradients consistent with nonhuman primate tract-tracing studies, characterized for each frontal voxel the striatal peak connectivity location on this gradient (PeaCoG), and tested for group differences and associations with clinical variables. We identified a cluster in the right orbitofrontal cortex (rOFC) with a peak connectivity shift towards ventral striatal regions in AUD. Reduced variability of rOFC striatal peak connectivity in the AUD group suggests a "clamping" to the ventral striatum as the underlying effect. Within the AUD group striatal peak connectivity in the superior frontal gyrus was associated with self-efficacy to abstain from alcohol, in the medial frontal and dorsolateral prefrontal cortex with alcohol dependency, and in the right inferior frontal gyrus with the urge to consume alcohol. Our results demonstrate that the functional topography of frontostriatal circuits exhibits interindividual variability, which provides insight into frontostriatal network adaptations in AUD and potentially other mental disorders.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1245-1253Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : 01GQ1003B
Pays : International
Organisme : Bundesministerium für Bildung und Forschung
ID : 01ZX1311A
Pays : International
Organisme : Horizon 2020 Framework Programme
ID : No 668863 (SyBil-AA)
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB 636/D6
Pays : International
Informations de copyright
© 2018 Society for the Study of Addiction.
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