Lack of thiazide diuretic inhibition of agonist constriction of mouse mesenteric arterioles ex vivo.
Animals
Arterioles
/ drug effects
Diuretics
/ pharmacology
Female
Hydrochlorothiazide
/ pharmacology
Male
Mesentery
/ blood supply
Mice, Inbred C57BL
Mice, Knockout
Phenylephrine
/ pharmacology
Solute Carrier Family 12, Member 3
/ genetics
Vasoconstriction
/ drug effects
Vasoconstrictor Agents
/ pharmacology
Constriction
Hydrochlorothiazide (HCTZ)
Mesentery
Na+/Cl− cotransporter (NCC)
Phenylephrine
Journal
Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 1432-1912
Titre abrégé: Naunyn Schmiedebergs Arch Pharmacol
Pays: Germany
ID NLM: 0326264
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
05
10
2018
accepted:
15
11
2018
pubmed:
25
11
2018
medline:
4
12
2019
entrez:
25
11
2018
Statut:
ppublish
Résumé
The chronic reduction of arterial blood pressure by thiazide diuretics (TZD) in hypertensive patients is mediated through an extra-renal mechanism. It is widely held that this extra-renal mechanism is a direct TZD inhibition of vasoconstriction. This study tested whether the TZD, hydrochlorothiazide (HCTZ), inhibited agonist constriction of mesenteric arterioles ex vivo. Mice deficient in the kidney distal convoluted tubule Na
Identifiants
pubmed: 30470918
doi: 10.1007/s00210-018-1590-5
pii: 10.1007/s00210-018-1590-5
pmc: PMC6327843
mid: NIHMS1004724
doi:
Substances chimiques
Diuretics
0
Solute Carrier Family 12, Member 3
0
Vasoconstrictor Agents
0
Hydrochlorothiazide
0J48LPH2TH
Phenylephrine
1WS297W6MV
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-121Subventions
Organisme : Professional Development Grant from the University of Cincinnati
ID : none
Pays : International
Organisme : U.S. Department of Veterans Affairs
ID : 5 I01 BX001000-06
Pays : International
Organisme : NIA NIH HHS
ID : R01 AG053585
Pays : United States
Organisme : Gheens Foundation
ID : none
Pays : International
Organisme : NIH HHS
ID : AG053585
Pays : United States
Organisme : BLRD VA
ID : I01 BX001000
Pays : United States
Organisme : Jewish Heritage Fund for Excellence
ID : none
Pays : International
Organisme : US Renal Care Inc
ID : none
Pays : International
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