[Hemorrhagic syndrome due to a heparin-like anticoagulant in a patient with systemic lupus erythematosus].
Syndrome hémorragique dû à un anticoagulant héparine-like chez un patient lupique.
Anticoagulant héparine-like
Hemorrhagic syndrome
Heparin-like anticoagulant
Lupus erythémateux disséminé
Macrophagic activation syndrome
Syndrome d’activation macrophagique
Syndrome hémorragique
Systemic lupus erythematosus
Journal
La Revue de medecine interne
ISSN: 1768-3122
Titre abrégé: Rev Med Interne
Pays: France
ID NLM: 8101383
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
09
01
2018
revised:
15
10
2018
accepted:
29
10
2018
pubmed:
26
11
2018
medline:
28
12
2019
entrez:
26
11
2018
Statut:
ppublish
Résumé
In systemic lupus erythematosus, hemostasis disorders are mainly thrombotic, but more rarely hemorrhagic. A 25-year-old man presented with a macrophagic activation syndrome revealing a systemic lupus erythematosus, secondarily complicated by a hemorrhagic syndrome ; biological investigations revealed an increase thrombin time and an activated partial thromboplastin time, normalized by protamin neutralization in vitro, thus confirming the presence of a heparin-like anticoagulant. The hemostasis balance normalized after the specific treatment of lupus. This rare anomaly of hemostasis balance has been described in blood cancers and solid cancers. This is the first description of a case associated with an autoimmune connective tissue disorder such as lupus. After one year of follow-up, no diagnosis of blood or solid cancer was made.
Identifiants
pubmed: 30471875
pii: S0248-8663(18)31165-2
doi: 10.1016/j.revmed.2018.10.390
pii:
doi:
Substances chimiques
Anticoagulants
0
Autoantibodies
0
Factor VIII
9001-27-8
Heparin
9005-49-6
Types de publication
Case Reports
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
184-187Informations de copyright
Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.