Resting state functional connectivity patterns associated with pharmacological treatment resistance in temporal lobe epilepsy.
Adult
Anticonvulsants
/ adverse effects
Brain
/ diagnostic imaging
Drug Resistant Epilepsy
/ diagnostic imaging
Epilepsy, Temporal Lobe
/ diagnostic imaging
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways
/ diagnostic imaging
Oxygen
/ blood
Rest
Retrospective Studies
Biomarker
Epilepsy
Resting State fMRI
Temporal lobe epilepsy
Treatment response
fMRI
Journal
Epilepsy research
ISSN: 1872-6844
Titre abrégé: Epilepsy Res
Pays: Netherlands
ID NLM: 8703089
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
01
09
2018
revised:
20
10
2018
accepted:
06
11
2018
pubmed:
26
11
2018
medline:
5
6
2019
entrez:
26
11
2018
Statut:
ppublish
Résumé
There are no functional imaging based biomarkers for pharmacological treatment response in temporal lobe epilepsy (TLE). In this study, we investigated whether there is an association between resting state functional brain connectivity (RsFC) and seizure control in TLE. We screened a large database containing resting state functional magnetic resonance imaging (Rs-fMRI) data from 286 epilepsy patients. Patient medical records were screened for seizure characterization, EEG reports for lateralization and location of seizure foci to establish uniformity of seizure localization within patient groups. Rs-fMRI data from patients with well-controlled left TLE, patients with treatment-resistant left TLE, and healthy controls were analyzed. Healthy controls and cTLE showed similar functional connectivity patterns, whereas trTLE exhibited a significant bilateral decrease in thalamo-hippocampal functional connectivity. This work is the first to demonstrate differences in neural network connectivity between well-controlled and treatment-resistant TLE. These differences are spatially highly focused and suggest sites for the etiology and possibly treatment of TLE. Altered thalamo-hippocampal RsFC thus is a potential new biomarker for TLE treatment resistance.
Identifiants
pubmed: 30472489
pii: S0920-1211(18)30438-8
doi: 10.1016/j.eplepsyres.2018.11.002
pmc: PMC6483378
mid: NIHMS1516964
pii:
doi:
Substances chimiques
Anticonvulsants
0
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-43Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
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