Lack of T-cell-mediated IL-2 and TNFα production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection.
Animals
B-Lymphocytes
/ immunology
CD58 Antigens
/ biosynthesis
Gene Expression
Interleukin-2
/ metabolism
Intestinal Mucosa
/ pathology
Intraepithelial Lymphocytes
/ immunology
Lymphocyte Activation
Macaca
Plasma
/ virology
Simian Acquired Immunodeficiency Syndrome
/ pathology
Simian Immunodeficiency Virus
/ isolation & purification
Tumor Necrosis Factor-alpha
/ metabolism
Viral Load
CD2
CD58
SIV
cytokine
mucosal immunology
Journal
The Journal of general virology
ISSN: 1465-2099
Titre abrégé: J Gen Virol
Pays: England
ID NLM: 0077340
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
pubmed:
28
11
2018
medline:
24
10
2019
entrez:
28
11
2018
Statut:
ppublish
Résumé
For an effective T-cell activation and response, co-stimulation is required in addition to the antigen-specific signal from their antigen receptors. The CD2/CD58 interaction is considered as one of the most important T-cell co-stimulatory pathways for T-cell activation and proliferation, and its role in regulating intestinal T-cell function in acute and chronic SIV -infected macaques is poorly documented. Here, we demonstrated a significant reduction of CD58 expression in both T- and B-cell populations during acute SIV infection along with high plasma viral load and a loss of intestinal CD4
Identifiants
pubmed: 30480508
doi: 10.1099/jgv.0.001181
pmc: PMC6537620
doi:
Substances chimiques
CD58 Antigens
0
Interleukin-2
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
26-34Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103458
Pays : United States
Organisme : NIH HHS
ID : P51 OD011104
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK109883
Pays : United States
Références
J Virol. 2014 Aug;88(16):9442-57
pubmed: 24920807
Clin Immunol. 2011 Sep;140(3):223-8
pubmed: 21622026
Immunology. 2000 Oct;101(2):169-77
pubmed: 11012769
Cell Immunol. 2004 May;229(1):1-12
pubmed: 15331323
Nature. 1987 Mar 26-Apr 1;326(6111):400-3
pubmed: 2951597
Blood. 2008 Dec 15;112(13):4981-90
pubmed: 18820133
J Virol. 2013 Mar;87(5):2628-38
pubmed: 23255798
J Virol. 2013 Apr;87(8):4584-95
pubmed: 23408608
PLoS One. 2014 Feb 13;9(2):e87873
pubmed: 24551068
Blood. 2007 Aug 15;110(4):1207-14
pubmed: 17513617
Gastroenterology. 1999 Mar;116(3):557-65
pubmed: 10029614
AIDS Res Hum Retroviruses. 1998 Apr;14 Suppl 1:S125-30
pubmed: 9581896
J Virol. 2013 Feb;87(3):1528-43
pubmed: 23152518
J Immunol. 2011 Jan 15;186(2):745-53
pubmed: 21148794
Nat Med. 1996 Oct;2(10):1084-9
pubmed: 8837605
AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1691-701
pubmed: 10606092
PLoS Pathog. 2016 Feb 01;12(2):e1005412
pubmed: 26829644
J Clin Invest. 1996 Dec 1;98(11):2616-22
pubmed: 8958226
J Virol. 2000 Mar;74(5):2255-64
pubmed: 10666256
Eur J Immunol. 2006 Mar;36(3):583-92
pubmed: 16506292
J Virol. 2013 Nov;87(21):11916-23
pubmed: 23966391
Front Biosci. 2006 Jan 01;11:788-803
pubmed: 16146771
Clin Immunol. 2015 May;158(1):8-18
pubmed: 25769244
J Acquir Immune Defic Syndr. 2013 Dec 1;64(4):332-41
pubmed: 23799411
Cell Immunol. 1997 Feb 25;176(1):82-91
pubmed: 9070321
J Virol. 2014 Nov;88(22):13015-28
pubmed: 25165117
J Immunol. 2009 Jun 15;182(12):7672-80
pubmed: 19494291
Immunol Today. 1996 Apr;17(4):177-87
pubmed: 8871350
J Exp Med. 1998 Dec 21;188(12):2199-204
pubmed: 9858506
Int Immunol. 1994 May;6(5):701-9
pubmed: 7521667
PLoS One. 2011;6(11):e27207
pubmed: 22096538
Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G671-7
pubmed: 19109405
Virology. 2009 May 10;387(2):273-84
pubmed: 19298994
ISRN AIDS. 2013 Aug 12;2013:954806
pubmed: 24052891
Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4180-3
pubmed: 23341590
Eur J Immunol. 2016 Oct;46(10):2420-2425
pubmed: 27469079
Virol J. 2016 Dec 1;13(1):200
pubmed: 27903274
J Immunol. 2015 Jul 15;195(2):477-87
pubmed: 26041540
Int Immunol. 2001 Feb;13(2):181-91
pubmed: 11157851
Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1019-23
pubmed: 9927686
Virology. 2007 Jun 20;363(1):36-47
pubmed: 17307212