Evaluation of Emergent Mutations in Circulating Cell-Free DNA and Clinical Outcomes in Patients with Metastatic Colorectal Cancer Treated with Panitumumab in the ASPECCT Study.
Adult
Biomarkers, Tumor
/ blood
Cell-Free Nucleic Acids
/ blood
Colorectal Neoplasms
/ blood
Disease-Free Survival
ErbB Receptors
/ blood
Female
Gene Frequency
Genetic Heterogeneity
High-Throughput Nucleotide Sequencing
Humans
Male
Middle Aged
Mutant Proteins
/ blood
Mutation
Neoplasm Metastasis
Panitumumab
/ administration & dosage
Prognosis
Proto-Oncogene Proteins B-raf
/ genetics
Proto-Oncogene Proteins p21(ras)
/ genetics
Signal Transduction
/ drug effects
Treatment Outcome
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
29
06
2018
revised:
10
10
2018
accepted:
19
11
2018
pubmed:
30
11
2018
medline:
21
4
2020
entrez:
30
11
2018
Statut:
ppublish
Résumé
Mutations in Plasma samples collected from panitumumab-treated patients in the ASPECCT study at baseline and safety follow-up (SFU) were analyzed by a next-generation sequencing-based approach for extended Overall, 261 patients in the panitumumab arm had evaluable plasma samples. Patients with a higher When mutations in
Identifiants
pubmed: 30487126
pii: 1078-0432.CCR-18-2072
doi: 10.1158/1078-0432.CCR-18-2072
doi:
Substances chimiques
Biomarkers, Tumor
0
Cell-Free Nucleic Acids
0
KRAS protein, human
0
Mutant Proteins
0
Panitumumab
6A901E312A
EGFR protein, human
EC 2.7.10.1
ErbB Receptors
EC 2.7.10.1
BRAF protein, human
EC 2.7.11.1
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Clinical Trial, Phase III
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1216-1225Informations de copyright
©2018 American Association for Cancer Research.