Antifungal activity of a de novo synthetic peptide and derivatives against fungal food contaminants.
Amino Acid Sequence
Amino Acid Substitution
Animals
Antifungal Agents
/ chemical synthesis
Antimicrobial Cationic Peptides
/ chemical synthesis
Aspergillus niger
/ drug effects
Caco-2 Cells
Dipeptides
Erythrocytes
/ drug effects
Food Contamination
/ prevention & control
Fruit and Vegetable Juices
/ microbiology
Fusarium
/ drug effects
Hemolysis
/ drug effects
Hot Temperature
Humans
Hydrogen-Ion Concentration
Malus
/ drug effects
Mice
Microbial Sensitivity Tests
Penicillium
/ drug effects
Phenylalanine
/ analogs & derivatives
Protein Structure, Secondary
RAW 264.7 Cells
Sheep
Sodium Chloride
/ pharmacology
Spores, Fungal
/ drug effects
Stereoisomerism
Structure-Activity Relationship
antimicrobial peptide
cytotoxicity
d-enantiomer
food spoilage
substitutions
Journal
Journal of peptide science : an official publication of the European Peptide Society
ISSN: 1099-1387
Titre abrégé: J Pept Sci
Pays: England
ID NLM: 9506309
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
19
07
2018
revised:
26
10
2018
accepted:
02
11
2018
pubmed:
30
11
2018
medline:
26
2
2019
entrez:
30
11
2018
Statut:
ppublish
Résumé
The development of novel solutions to fight microbial food contaminants rests upon two pillars, which are the development of resistant strains and consumers' desire for a reduced consumption of synthetic drugs. Natural antimicrobial peptides possess the qualities to overcome these issues. De novo synthesis of novel antifungal compounds is a major progress that has been facilitated by the identification of parameters involved in the antimicrobial activity. A 14-residue peptide named KK14, with the sequence KKFFRAWWAPRFLK-NH
Substances chimiques
Antifungal Agents
0
Antimicrobial Cationic Peptides
0
Dipeptides
0
phenylalanylphenylalanine
2577-40-4
Sodium Chloride
451W47IQ8X
Phenylalanine
47E5O17Y3R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3137Subventions
Organisme : Irish Department of Agriculture, Food and the Marine
ID : FIRM/RSF/CoFoRD (13/F/462)
Informations de copyright
© 2018 European Peptide Society and John Wiley & Sons, Ltd.